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Calculates the age-adjusted D-dimer threshold for pulmonary embolism (PE) exclusion. The standard D-dimer threshold of 500 µg/L FEU has high sensitivity but low specificity in older adults, leading to unnecessary CT pulmonary angiography. The age-adjusted threshold (age × 10 µg/L FEU for patients ≥50 years) was validated in the ADJUST-PE study and maintains safety while reducing imaging rates by approximately 30% in elderly patients with low-to-intermediate PE probability.
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