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Identifies patients with acute kidney injury (AKI) who have clinical and laboratory features most consistent with acute interstitial nephritis (AIN) as opposed to other AKI etiologies (pre-renal, ATN, obstruction, glomerulonephritis). AIN accounts for 15–25% of AKI biopsies and is importantly a reversible cause if the offending drug or trigger is removed promptly. The score uses clinical and urinalysis features to support pre-biopsy risk stratification.
Recent Exposure to AIN-Associated Drug (< 3 Months)
Urine Eosinophils Positive (Hansel or Wright Stain)
Sterile Pyuria (WBCs in Urine Without Bacteriuria)
WBC Casts on Urine Microscopy
No Proteinuria > 1 g/day and No Hematuria (Bland Urine Sediment Beyond Pyuria)
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