1. Temperature — Rectal (°C)

≥ 41°C or ≤ 29.9°C (extreme hyper/hypothermia)+439–40.9°C (high fever)+330–31.9°C (hypothermia)+338.5–38.9°C (low-grade fever)+132–33.9°C (mild hypothermia)+234–35.9°C (borderline low)+136–38.4°C (normal)+0

2. Mean Arterial Pressure (MAP) — mmHg

MAP ≥ 160 mmHg or ≤ 49 mmHg (extreme values)+4MAP 130–159 mmHg+3MAP 110–129 mmHg or 50–69 mmHg+2MAP 70–109 mmHg (normal)+0

3. Heart Rate (bpm)

HR ≥ 180 bpm or ≤ 39 bpm (extreme values)+4HR 140–179 bpm or 40–54 bpm+3HR 110–139 bpm or 55–69 bpm+2HR 70–109 bpm (normal)+0

4. Respiratory Rate (breaths/min)

5. Oxygenation

FiO2 ≥ 0.5: A-aDO2 ≥ 500 mmHg+4FiO2 ≥ 0.5: A-aDO2 350–499 mmHg+3FiO2 ≥ 0.5: A-aDO2 200–349 mmHg+2FiO2 ≥ 0.5: A-aDO2 < 200 mmHg+0FiO2 < 0.5: PaO2 > 70 mmHg (normal)+0FiO2 < 0.5: PaO2 61–70 mmHg+1FiO2 < 0.5: PaO2 55–60 mmHg+3FiO2 < 0.5: PaO2 < 55 mmHg+4

6. Arterial pH

7. Serum Sodium (mEq/L)

8. Serum Potassium (mEq/L)

9. Serum Creatinine (mg/dL) — Score DOUBLED if Acute Renal Failure (ARF) present

Cr ≥ 3.5, no ARF (4 pts)+4Cr ≥ 3.5, with ARF (doubled: 8 pts)+8Cr 2.0–3.4, no ARF (3 pts)+3Cr 2.0–3.4, with ARF (doubled: 6 pts)+6Cr 1.5–1.9, no ARF (2 pts)+2Cr 1.5–1.9, with ARF (doubled: 4 pts)+4Cr 0.6–1.4 mg/dL (normal)+0Cr < 0.6 mg/dL+2

10. Hematocrit (%)

11. White Blood Cell Count (×10³ cells/µL)

WBC ≥ 40 or < 1 (×10³/µL) — extreme values+4WBC 20–39.9 (leukocytosis)+2WBC 1–2.9 (severe leukopenia)+2WBC 15–19.9+1WBC 3–14.9 (×10³/µL) — normal range+0

12. Glasgow Coma Scale (GCS) — Contribution to APS = 15 − GCS

GCS 15 (normal) — 0 APS points+0GCS 14 — 1 APS point+1GCS 13 — 2 APS points+2GCS 11–12 — 3–4 APS points (use 3)+3GCS 9–10 — 5–6 APS points (use 5)+5GCS 7–8 — 7–8 APS points (use 7)+7GCS 5–6 — 9–10 APS points (use 9)+9GCS 3–4 — 11–12 APS points (use 11)+11

13. Age Points

Age ≤ 44 years — 0 age points+0Age 45–54 years — 2 age points+2Age 55–64 years — 3 age points+3Age 65–74 years — 5 age points+5Age ≥ 75 years — 6 age points+6

14. Chronic Health Points

No significant organ insufficiency or immunocompromise — 0 chronic health points+0Elective surgical patient with severe organ insufficiency or immunocompromise — 2 chronic health points+2Nonoperative or emergency surgical patient with severe organ insufficiency or immunocompromise — 5 chronic health points+5

APACHE II Score (Acute Physiology and Chronic Health Evaluation II)

APACHE II Score (Acute Physiology and Chronic Health Evaluation II)