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The Berlin Definition (2012) is the internationally accepted diagnostic framework for acute respiratory distress syndrome (ARDS). It replaced the 1994 American-European Consensus Conference (AECC) definition, which had poor inter-rater reliability and ambiguous criteria. The Berlin definition requires 3 prerequisite criteria (timing, chest imaging, origin of edema) and classifies ARDS severity into mild, moderate, and severe based on the PaO2/FiO2 (P/F) ratio with a minimum PEEP of 5 cmH₂O.
Acute Onset — Within 1 Week of Known Clinical Insult
Bilateral Opacities on CXR or CT Chest
Respiratory Failure Not Fully Explained by Cardiac Failure or Fluid Overload
PaO₂/FiO₂ Ratio (with PEEP or CPAP ≥ 5 cmH₂O)
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