Age > 60 Years

Age ≤ 60 years (0 pts)+0Age > 60 years (+1 pt)+1

ECOG Performance Status ≥ 2

ECOG 0–1 (ambulatory, working or independent) (0 pts)+0ECOG ≥ 2 (limited self-care or worse) (+1 pt)+1

LDH > Upper Limit of Normal

LDH normal (0 pts)+0LDH elevated above ULN (+1 pt)+1

Ann Arbor Stage III–IV

Stage I–II (0 pts)+0Stage III–IV (+1 pt)+1

> 1 Extranodal Disease Site

0–1 extranodal site (0 pts)+0> 1 extranodal site (+1 pt)+1

Kidney and/or Adrenal Involvement

No renal or adrenal involvement (0 pts)+0Kidney and/or adrenal involvement (+1 pt)+1

CNS-IPI — Central Nervous System International Prognostic Index for DLBCL