Diagnostic criteria for infective endocarditis combining major (blood culture, echocardiographic) and minor (predisposing conditions, fever, vascular phenomena) criteria.

Parameters

Major Criteriamajor

Typical microorganisms from ≥2 blood culturesS. viridans, S. bovis, HACEK group, S. aureus, or community-acquired Enterococcus (without primary focus)Persistently positive blood culturesSame organism from ≥2 cultures drawn >12h apart, OR all of ≥3 or most of ≥4 separate cultures (first and last drawn ≥1h apart)Single positive blood culture for Coxiella burnetii or Phase 1 IgG titer >1:800Echocardiogram positive for IEOscillating intracardiac mass on valve or supporting structure, in the path of regurgitant jetsEchocardiographic evidence of abscess, pseudoaneurysm, or intracardiac fistulaNew valvular regurgitation (worsening or changing pre-existing murmur not sufficient)

Minor Criteriaminor

Predisposing heart condition or injection drug useProsthetic valve, previous IE, congenital heart disease, valvular dysfunction, IVDUFever (temperature ≥38°C / 100.4°F)Vascular phenomenaMajor arterial emboli, septic pulmonary infarcts, mycotic aneurysm, intracranial hemorrhage, conjunctival hemorrhages, Janeway lesionsImmunological phenomenaGlomerulonephritis, Osler nodes, Roth spots, rheumatoid factorMicrobiological evidence not meeting major criterionPositive blood culture not meeting above major criterion, or serological evidence of active infection with organism consistent with IE

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CalculatorsDuke Criteria for Infective Endocarditis

Infectious DiseaseCriteria

Duke Criteria for Infective Endocarditis

Diagnostic criteria for infective endocarditis combining major (blood culture, echocardiographic) and minor (predisposing conditions, fever, vascular phenomena) criteria.

Parameters

Major Criteriamajor

Typical microorganisms from ≥2 blood culturesS. viridans, S. bovis, HACEK group, S. aureus, or community-acquired Enterococcus (without primary focus)Persistently positive blood culturesSame organism from ≥2 cultures drawn >12h apart, OR all of ≥3 or most of ≥4 separate cultures (first and last drawn ≥1h apart)Single positive blood culture for Coxiella burnetii or Phase 1 IgG titer >1:800Echocardiogram positive for IEOscillating intracardiac mass on valve or supporting structure, in the path of regurgitant jetsEchocardiographic evidence of abscess, pseudoaneurysm, or intracardiac fistulaNew valvular regurgitation (worsening or changing pre-existing murmur not sufficient)

Minor Criteriaminor

Predisposing heart condition or injection drug useProsthetic valve, previous IE, congenital heart disease, valvular dysfunction, IVDUFever (temperature ≥38°C / 100.4°F)Vascular phenomenaMajor arterial emboli, septic pulmonary infarcts, mycotic aneurysm, intracranial hemorrhage, conjunctival hemorrhages, Janeway lesionsImmunological phenomenaGlomerulonephritis, Osler nodes, Roth spots, rheumatoid factorMicrobiological evidence not meeting major criterionPositive blood culture not meeting above major criterion, or serological evidence of active infection with organism consistent with IE

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