EPIPHANY Index — Pulmonary Hypertension Risk Severity Score

The EPIPHANY Index (Estimates of Pulmonary Hypertension Index for Near-term prognosis in ANCHOR registry) is a simplified risk stratification score for patients with group 1 pulmonary arterial hypertension (PAH) to predict clinical worsening and mortality. It incorporates right heart catheterization hemodynamic parameters with clinical status to facilitate pulmonary hypertension management decisions and treatment escalation. The EPIPHANY approach simplifies the multi-dimensional European PAH risk assessment (COMPERA, REVEAL 2.0) while maintaining prognostic discrimination.