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A 5-point clinical prediction rule developed from UK primary care to guide antibiotic prescribing in adults and children presenting with acute sore throat. FeverPAIN stratifies the probability of Group A Streptococcus (GAS) pharyngitis and recommends immediate antibiotics, delayed prescribing, or no antibiotics based on the score. Validated in the DESCARTE and PRISM trials.
F — Fever (Temperature ≥38°C / 100.4°F in Past 24 Hours)
P — Purulence (Purulent Tonsils / Tonsillar Exudate)
A — Attend Rapidly (Symptom Onset ≤3 Days Before Presentation)
I — Inflamed Tonsils (Severe Tonsil Inflammation)
N — No Cough or Coryza (Absence of Both)
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