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The GARFIELD-AF (Global Anticoagulant Registry in the FIELD-Atrial Fibrillation) Risk Score is a validated prediction model derived from a large multinational real-world registry of > 50,000 patients with newly diagnosed non-valvular atrial fibrillation to simultaneously predict 1-year all-cause mortality, stroke/systemic embolism, and major bleeding. Unlike CHA₂DS₂-VASc which only predicts stroke risk, GARFIELD-AF provides competing risk estimates to aid in the individualized benefit-risk assessment of anticoagulation therapy — allowing comparison of ischemic stroke prevention benefit vs. bleeding risk for individual AF patients.
Age
Female Sex
Heart Failure (any EF) or LVEF < 40%
Diabetes Mellitus
Prior Stroke, TIA, or Systemic Embolism
Coronary Artery Disease (prior MI, angina, PCI, CABG)
Chronic Kidney Disease (CKD — any stage)
Hypertension (on antihypertensive therapy OR BP > 140/90 mmHg)
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