Lille Score — Steroid Response in Alcoholic Hepatitis

The Lille Score predicts 6-month mortality in patients with severe alcoholic hepatitis (AH) who are receiving corticosteroid (prednisolone) therapy, by assessing response to treatment at Day 7. A Lille Score ≥ 0.45 identifies non-responders — patients who fail to demonstrate hepatic improvement on steroids — in whom continued steroid therapy is futile and associated with increased infection risk. First described by Louvet et al. (2007), the Lille Score is the standard clinical tool for 7-day steroid response assessment in severe AH.