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The Lung Injury Prediction Score (LIPS) is a validated clinical scoring tool developed to identify patients at high risk of developing Acute Respiratory Distress Syndrome (ARDS) — allowing early identification of at-risk patients for either preventive interventions or enrollment in prophylactic ARDS trials. LIPS was derived and externally validated in a large prospective multicenter US cohort (Lung Injury Prevention Study — LIPS) and incorporates predisposing conditions, high-risk diagnoses, and modifiable risk factors. Unlike ARDS Berlin Criteria (which diagnose established ARDS), LIPS predicts ARDS development BEFORE lung injury occurs.
Primary Predisposing Condition (select one — highest contributor)
Obesity (BMI ≥ 30)
History of Alcohol Abuse or Current Heavy Alcohol Use (> 14 drinks/week)
Hypoalbuminemia (Albumin < 3.0 g/dL) or Nutritional Deficiency
Tachypnea (RR > 30 breaths/min at initial assessment)
SpO₂ < 95% on Room Air or Supplemental Oxygen Requirement
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