Burden of Febrile Neutropenia / Severity of Illness

No or mild symptoms — Patient appears well, stable, ambulatory+5Moderate symptoms — Significant but not life-threatening illness+3Severe symptoms or life-threatening illness — Sepsis, hemodynamic instability+0

No Hypotension at Presentation

No hypotension (SBP > 90 mmHg, not on vasopressors)+5Hypotension present (SBP ≤ 90 mmHg or vasopressor-dependent)+0

No COPD (Active Chronic Obstructive Pulmonary Disease)

No active COPD+4Active COPD (requires regular inhalers/treatment)+0

Solid Tumor OR Hematologic Malignancy with No Previous Fungal Infection

Solid tumor — any solid malignancy+4Hematologic malignancy with no previous fungal infection+4Hematologic malignancy WITH previous fungal infection+0

No Dehydration Requiring IV Fluids

No dehydration requiring IV fluids+3Dehydration requiring IV fluid administration+0

Outpatient Status at Time of Febrile Neutropenia Onset

Outpatient — FN developed at home, not already hospitalized+3Inpatient — Already hospitalized when FN developed+0

Age < 60 Years

Age < 60 years+2Age ≥ 60 years+0

MASCC Risk Index for Febrile Neutropenia

MASCC Risk Index for Febrile Neutropenia