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The Pulmonary Embolism Sub-massive At-Risk for Deterioration (PE-SARD) score is designed to identify intermediate-high risk (sub-massive) pulmonary embolism patients who are most likely to deteriorate or fail initial anticoagulation monotherapy — thereby identifying which patients may benefit from early reperfusion strategies (catheter-directed therapy, systemic thrombolysis, or surgical embolectomy) rather than expectant anticoagulation alone. The score addresses the clinical dilemma of managing the large 'gray zone' intermediate-risk PE patients where optimal management (anticoagulation vs. reperfusion vs. monitoring) is uncertain.
Troponin Elevation (Troponin I > 0.4 ng/mL or high-sensitivity troponin above 99th percentile)
BNP or NT-proBNP Elevation
RV/LV Ratio on CTPA or Echocardiography
Right Ventricular Dysfunction on Echocardiography (hypokinesis, McConnell sign, septal flattening)
Clot Burden (PE obstruction index — large bilateral clots, saddle embolus, bilobar involvement)
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