P — Platelet Count < 30 × 10⁹/L (30,000/µL)

No — Platelet count ≥ 30 × 10⁹/L+0Yes — Platelet count < 30 × 10⁹/L+1

L — Combined Hemolysis Variable (Any One of the Following)

No — None of the hemolysis markers present+0Yes — Reticulocytes > 2.5%, OR haptoglobin undetectable, OR indirect bilirubin > 2 mg/dL+1

A — No Active Cancer

No — Active cancer present (currently under treatment)+0Yes — No active cancer+1

S — No Stem Cell or Solid Organ Transplant History

No — History of stem cell or solid organ transplant+0Yes — No transplant history+1

M — Mean Corpuscular Volume (MCV) < 90 fL

No — MCV ≥ 90 fL (normal or macrocytic)+0Yes — MCV < 90 fL (microcytic or normocytic)+1

I — INR < 1.5

No — INR ≥ 1.5 (suggests DIC, liver disease)+0Yes — INR < 1.5 (coagulation relatively preserved)+1

C — Creatinine < 2.0 mg/dL (< 177 µmol/L)

No — Creatinine ≥ 2.0 mg/dL (suggests HUS rather than TTP)+0Yes — Creatinine < 2.0 mg/dL (renal function relatively preserved)+1

PLASMIC Score for Thrombotic Thrombocytopenic Purpura (TTP)