Recent Major Bleeding (Within 30 Days Prior to VTE Diagnosis)

No major bleeding in the past 30 days+0Major bleeding event within the past 30 days+2

Creatinine > 1.2 mg/dL (> 106 µmol/L)

Creatinine ≤ 1.2 mg/dL — normal renal function+0Creatinine > 1.2 mg/dL — impaired renal function+1.5

Anemia at Presentation

No anemia (Hgb ≥ 13 g/dL in men, ≥ 12 g/dL in women)+0Anemia present (Hgb < 13 g/dL men, or < 12 g/dL women)+1.5

Active Cancer

No active cancer+0Active cancer (currently under treatment)+1

Clinically Overt PE at Presentation (vs. DVT Alone)

Isolated DVT (no pulmonary embolism)+0Pulmonary embolism at presentation (with or without DVT)+1

Age > 75 Years

Age ≤ 75 years+0Age > 75 years+1

RIETE Score — Bleeding Risk During Anticoagulation for VTE