SIC Score — Sepsis-Induced Coagulopathy Score

The Sepsis-Induced Coagulopathy (SIC) Score is a bedside tool derived from the International Society on Thrombosis and Haemostasis (ISTH) that identifies patients with sepsis-induced coagulopathy — a precursor state to overt DIC (disseminated intravascular coagulation). SIC is diagnosed using: INR, platelet count, and total SOFA score. A SIC Score ≥ 4 identifies patients with sepsis who may benefit from anticoagulation therapy (particularly heparin). This score was the stratification tool used in the multicenter HESACOV/JMHW heparin studies.