Dexmedetomidine

For Adult Intensive Care Unit Sedation : • Initiate at one mcg/kg over 10 minutes , followed by a maintenance infusion of 0.2 to 0.7 mcg/kg/ hour . •

For Adult Procedural Sedation : Initiate at one mcg/kg over 10 minutes , followed by a maintenance infusion initiated at 0.6 mcg/kg/ hour and titrated to achieve desired clinical effect with doses ranging from 0.2 to 1 mcg/kg/ hour . • Alternative Doses : Recommended for patients over 65 years of age and awake fiberoptic intubation patients. • See full prescribing information for recommended dosage, reconstitution, dilution, and administration instructions. (2.2, 2.3, 2.4 ,2.5, 2.6, 2.7) 2.1 Administration Instructions • Individualize and titrate dosing to desired clinical response. • Administer by continuous intravenous infusion using a controlled infusion device. • Administration duration should not exceed 24 hours .

Recommended Dosage in Adult Patients INDICATIONInitiation of Intensive Care Unit Sedation For

For patients over 65 years of age: Consider a dose reduction .

For adult patients with impaired hepatic function: Consider a dose reduction . Maintenance of Intensive Care Unit Sedation For

For patients over 65 years of age: Consider a dose reduction .

For adult patients with impaired hepatic function: Consider a dose reduction Initiation of Procedural Sedation For

adult patients: a loading infusion of one mcg/kg over 10 minutes . For less invasive procedures such as ophthalmic surgery, a loading infusion of 0.5 mcg/kg given over 10 minutes may be suitable. For awake fiberoptic intubation in

For patients over 65 years of age: a loading infusion of 0.5 mcg/kg over 10 minutes .

For adult patients with impaired hepatic function: Consider a dose reduction . Maintenance of Procedural Sedation For