Imatinib

Adults with Ph+ CML CP : 400 mg/day Adults with Ph+ CML AP or BC : 600 mg/day Pediatrics with Ph+ CML CP : 340 mg/m 2 /day Adults with Ph+ ALL : 600 mg/day Pediatrics with Ph+ ALL 340 mg/m 2 /day Adults with MDS/MPD : 400 mg/day Adults with ASM : 100 mg/day or 400 mg/day Adults with HES/CEL : 100 mg/day or 400 mg/day Adults with DFSP : 800 mg/day Adults with metastatic and/or unresectable GIST : 400 mg/day Adjuvant treatment of adults with GIST : 400 mg/day Patients with mild to moderate hepatic impairment : 400 mg/day Patients with severe hepatic impairment : 300 mg/day All doses of imatinib mesylate tablets should be taken with a meal and a large glass of water. Doses of 400 mg or 600 mg (imatinib as free base) should be administered once daily, whereas a dose of 800 mg (imatinib as free base) should be administered as 400 mg (imatinib as free base) twice a day. Imatinib mesylate tablets can be dissolved in water or apple juice for patients having difficulty swallowing. Daily dosing of 800 mg (imatinib as free base) and above should be accomplished using the 400 mg tablet (imatinib as free base) to reduce exposure to iron.