Metoprolol

Administer once daily with food or after a meal. Titrate at weekly or longer intervals as needed and tolerated. Hypertension: Recommended starting dosage is 100 mg daily, in single or divided doses. Angina Pectoris: Recommended starting dosage is 100 mg daily, given as two divided doses. Myocardial Infarction: The starting dosage depends upon tolerance of intravenous metoprolol, see full prescribing information. 2.1 Hypertension Individualize the dosage of metoprolol tartrate tablets. Metoprolol tartrate tablets should be taken with or immediately following meals. The usual initial dosage is 100 mg daily in single or divided doses. Adjust dosage at weekly (or longer) intervals until optimum blood pressure reduction is achieved. In general, the maximum effect of any given dosage level will be apparent after 1 week of therapy. The effective dosage range of metoprolol tartrate tablets is 100 mg to 450 mg per day. Dosages above 450 mg per day have not been studied. While once-daily dosing can maintain a reduction in blood pressure throughout the day, lower doses (especially 100 mg) may not maintain a full effect at the end of the 24-hour period.