Montelukast

for patients 2 years and older. • Acute prevention of EIB : One tablet at least 2 hours before exercise for patients 15 years of age and older. • Seasonal allergic rhinitis : Once daily

for patients 2 years and older. • Perennial allergic rhinitis : Once daily

for patients 2 years and older. Dosage (by age): • 15 years and older: one 10-mg tablet. • 2 to 5 years: one 4-mg chewable tablet . • 6 to 14 years: one 5-mg chewable tablet. Patients with both asthma and allergic rhinitis should take only one dose daily in the evening . 2.1 Asthma Montelukast sodium should be taken once daily in the evening. The following doses are recommended:

For adults and adolescents 15 years of age and older: one 10-mg tablet.

For pediatric patients 6 to 14 years of age: one 5-mg chewable tablet.

For pediatric patients 2 to 5 years of age: one 4-mg chewable tablet. Safety and effectiveness in pediatric patients less than 2 years of age with asthma have not been established. There have been no clinical trials in patients with asthma to evaluate the relative efficacy of morning versus evening dosing. The pharmacokinetics of montelukast are similar whether dosed in the morning or evening. Efficacy has been demonstrated for asthma when montelukast was administered in the evening without regard to time of food ingestion. 2.2 Exercise-Induced Bronchoconstriction (EIB) in Patients 15 Years of Age and Older For prevention of EIB, a single 10 mg dose of montelukast should be taken at least 2 hours before exercise.

for the treatment of symptoms of seasonal allergic rhinitis are recommended:

For adults and adolescents 15 years of age and older: one 10-mg tablet.

For pediatric patients 6 to 14 years of age: one 5-mg chewable tablet.

For pediatric patients 2 to 5 years of age: one 4-mg chewable tablet . Safety and effectiveness in pediatric patients younger than 2 years of age with seasonal allergic rhinitis have not been established. The following doses