Monotherapy: Rasagiline Tablets 1 mg once daily As adjunct without levodopa: Rasagiline Tablets 1 mg once daily As adjunct to levodopa: Rasagiline Tablets 0.5 mg once daily. Increase dose to 1 mg daily as needed for sufficient clinical response Patients taking ciprofloxacin or other CYP1A2 inhibitors: Rasagiline Tablets 0.5 mg once daily (2.2, 5.4) Patients with mild hepatic impairment: Rasagiline Tablets 0.5 mg once daily. Rasagiline Tablets should not be used in patients with moderate or severe hepatic impairment (2.3, 5.5) 2.1 General Dosing Recommendations When rasagiline tablets are prescribed as monotherapy or as adjunct therapy in patients not taking levodopa, patients may start rasagiline tablets at the recommended dose of 1 mg administered orally once daily. In patients taking levodopa, with or without other PD drugs (e.g., dopamine agonist, amantadine, anticholinergics), the recommended initial dose of rasagiline tablet is 0.5 mg once daily. If the patient tolerates the daily 0.5 mg dose, but a sufficient clinical response is not achieved, the dose may be increased to 1 mg once daily.
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