Tacrolimus

Capsules must be taken whole. Take consistently every morning at the same time on an empty stomach at least 1 hour before a meal or at least 2 hours after a meal. Avoid eating grapefruit or drinking grapefruit juice or alcohol. African-American patients and patients with severe hepatic impairment may require dosing adjustments. Frequent monitoring of trough concentrations is recommended. For complete dosing information, see Full Prescribing Information. MMF = Mycophenolate mofetil Recommended Tacrolimus Extended-Release Capsules Initial Dosage Patient Population Initial Oral Dosage Whole Blood Trough Concentration Range ADULT With basiliximab, MMF and steroids 0.15 mg/kg to 0.2 mg/kg once daily prior to reperfusion or within 48 hours of completion of transplant Month 1: 7 ng/mL to 15 ng/mL Month 2 to Month 6: 5 ng/mL to 15 ng/mL More than 6 Months: 5 ng/mL to 10 ng/mL With MMF and steroids, without basiliximab induction First dose (pre-operative): 0.1 mg/kg, within 12 hours prior to reperfusion Subsequent doses (post-operative): 0.2 mg/kg once daily at least 4 hours after pre-operative dose and within 12 hours after reperfusion Month 1: 10 ng/mL to 15 ng/mL Month 2 to Month 6: 5 ng...