CHIPS Trial (2015) — tight versus less-tight BP control in pregnancy
Target DBP 85 mmHg reduced severe hypertension without fetal harm
ASPRE Trial (2017) — aspirin 150 mg from 11–14 weeks in screen-positive patients
62% reduction in early-onset preeclampsia
Cochrane Review — Calcium Supplementation During Pregnancy (2025, Cluver et al.)
Significant reduction in preeclampsia incidence in low-calcium populations
Review articles
Magee LA, Nicolaides KH, von Dadelszen P — Preeclampsia. NEJM 2022
Ives CW et al. — Preeclampsia-Pathophysiology and Clinical Presentations. JACC 2020
Farahi N et al. — Hypertensive Disorders of Pregnancy. American Family Physician 2024
Palmiero P et al. — Long-Term Cardiovascular Risk and Maternal History of Pre-Eclampsia. J Clin Med 2025
Chang KJ et al. — Preeclampsia: Recent Advances. Int J Environ Res Public Health 2023
Coding references
ICD-10 O14.0 — preeclampsia without severe features
ICD-10 O14.1 — preeclampsia with severe features
ICD-10 O14.2 — HELLP syndrome
ICD-10 O13 — gestational hypertension
ICD-10 O11 — chronic hypertension with superimposed preeclampsia
ICD-10 O15 — eclampsia
SymptomDx is an educational tool for medical professionals. It does not replace clinical judgment. Verify all clinical data and drug dosages with authoritative sources.