Resuscitation and hemorrhage control
› Immediate stabilization bundle
› Positioning
› Left uterine displacement
› Supine avoidance if symptomatic hypotension
› Fluids and products
› Balanced crystalloid as bridge only
› Early blood products for ongoing hemorrhage
› Massive transfusion protocol
› If ongoing hemorrhage with shock, activate immediately
› Targeted hemostatic resuscitation with lab guided adjustments
› Temperature and calcium
› Active warming
› IV calcium replacement during high volume transfusion
Blood products and hemostasis
› Packed red blood cells
› Transfusion triggers individualized to shock and ongoing bleeding
› Goal perfusion and oxygen delivery rather than single hemoglobin number
› Plasma and platelets
› If coagulopathy with bleeding, plasma support
› If thrombocytopenia with bleeding or operative need, platelets support
› Fibrinogen replacement
› Cryoprecipitate or fibrinogen concentrate based on local protocol
› If fibrinogen low with bleeding, replace early
› Repeat fibrinogen monitoring after replacement
› Tranexamic acid
› If massive obstetric hemorrhage, consider per institutional obstetric hemorrhage protocol
› Greatest evidence base in postpartum hemorrhage
› Use in antepartum hemorrhage as specialist guided decision
Obstetric management and delivery planning
› Delivery strategy based on maternal and fetal status
› If maternal instability, expedited delivery decision with obstetrics
› Cesarean delivery if viable fetus and maternal condition allows
› Vaginal delivery pathway if fetal demise and maternal stabilization achievable
› If fetal distress with viable fetus, expedited delivery
› If stable and mild suspected abruption, expectant management in hospital with continuous monitoring
› Avoidance of tocolysis in significant abruption
› Ongoing bleeding as contraindication to tocolysis
› Specialist decision only in selected mild cases
› Analgesia and antiemetics
› Opioid analgesia titrated to effect with maternal monitoring
› Antiemetic therapy if vomiting contributes to distress
› Corticosteroids for fetal lung maturity
› If preterm viable gestation and expectant management planned, antenatal corticosteroids per obstetrics
› Magnesium sulfate
› If imminent preterm delivery for neuroprotection per obstetrics
› Hypertension management
› If severe range blood pressure, antihypertensive therapy per obstetrics protocol
› IV labetalol protocol
› Initiate 20 mg IV
› If inadequate response, 40 mg IV after 10 minutes
› If inadequate response, 80 mg IV every 10 minutes
› Maximum cumulative 220 mg
› IV hydralazine protocol
› Initiate 5 to 10 mg IV
› Repeat 5 to 10 mg IV every 20 to 40 minutes
› Oral nifedipine immediate release protocol
› Initiate 10 mg orally
› Repeat 20 mg orally after 20 minutes if needed
› Antibiotics
› Not routine for abruption alone
› If chorioamnionitis suspected, broad spectrum antibiotics per obstetrics protocol
› Rh negative patient pathway
› Rh immune globulin administration
› Dose per gestational age and fetomaternal hemorrhage testing
› Additional dosing guided by Kleihauer Betke or flow cytometry
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