›Open fracture requiring antibiotics and tetanus pathway first when feasible
›Analgesia and anesthesia
›Non-opioid base
›Acetaminophen 1000 mg PO
›Ibuprofen 400 to 600 mg PO if no contraindication
›Opioid options
›Morphine IV 0.05 mg per kg
›Re-dose every 5 to 10 minutes to effect
›Hold for respiratory depression
›Fentanyl IV 0.5 to 1 microgram per kg
›Re-dose every 5 minutes to effect
›Short duration advantage for brief manipulation
›Procedural sedation pathway when required
›Monitoring and readiness
›Continuous pulse oximetry
›Continuous ECG
›Blood pressure cycling every 3 to 5 minutes
›Sedative options
›Ketamine IV 1 mg per kg
›Additional 0.5 mg per kg as needed
›Emergence reaction risk counseling
›Propofol IV 0.5 mg per kg
›Additional 0.25 to 0.5 mg per kg titration
›Hypotension and apnea risk readiness
›Technique principles
›Gentle longitudinal traction and countertraction
›Avoid repeated forceful attempts
›Post-reduction requirements
›Immediate neurovascular re-check
›Post-reduction imaging
›Immobilization in position of stability
Open fracture medications and timing
›Antibiotics and duration concepts
›Early antibiotics reduce infection risk in open fractures :contentReference[oaicite:12]{index=12}
›Gustilo Type I and II typical regimen
›Cefazolin IV 2 g
›Repeat every 8 hours
›Stop 24 hours after wound closure guidance in trauma guidelines :contentReference[oaicite:13]{index=13}
›Gustilo Type III typical regimen
›Cefazolin IV 2 g
›Gentamicin IV 5 mg per kg once daily
›Duration up to 72 hours from injury or stop within 24 hours of soft tissue coverage guidance :contentReference[oaicite:14]{index=14}
›Clostridial contamination risk
›Penicillin addition described in open fracture prophylaxis reviews :contentReference[oaicite:15]{index=15}
›Tetanus prophylaxis logic
›Dirty wound with unknown or incomplete immunization history
›Tetanus immune globulin plus vaccine per local protocol
›Wound care
›Sterile saline-moistened dressing
›Avoid topical powders or ointments in ED wound
DVT prophylaxis when relevant
›Risk stratification and protocol alignment
›Lower limb immobilization can increase VTE risk
›Use local protocol and patient risk factors for decision
›High-risk features
›Prior VTE
›Active cancer
›Prolonged immobility
›Major trauma or surgery planned
›Common prophylaxis option when indicated
›Enoxaparin 40 mg SC daily
›Contraindications
›Active bleeding
›Severe thrombocytopenia
›High bleeding risk