›High efficacy including against pyrethroid-resistant lice
›Malathion 0.5% lotion (Ovide)
›Apply to dry hair; leave on 8 to 12 hours; rinse
›Repeat in 7 to 9 days if live lice remain
›Age: 6 years and older
›Flammable: avoid heat sources, hair dryers, open flames during application
›Unpleasant odor from isopropyl alcohol base
›Benzyl alcohol 5% lotion (Ulesfia)
›Apply to dry hair; leave on 10 minutes; rinse
›Repeat at day 9
›Age: 6 months and older
›Mechanism: suffocation; no neurotoxic resistance concerns
›Oral ivermectin
›Dose: 200 micrograms per kilogram body weight
›Repeat dose at 7 to 10 days
›Take with food to increase bioavailability
›Age and weight restriction
›Children 15 kg and older
›Use with caution in children under 15 kg due to blood-brain barrier immaturity
›Efficacy comparable to topical agents in resistant cases
›Class IIa recommendation for treatment-resistant head lice
Contraindicated treatments
›Lindane shampoo
›Not recommended due to neurotoxicity risk
›Seizure risk, especially in children under 10 years
›Contraindicated in pregnancy and breastfeeding
›Contraindicated in patients with extensive dermatitis
›Removed from many national formularies
›Animal-grade ivermectin products
›Never appropriate for human use
›Concentration and excipients differ from human-grade formulations
›Hygiene and clothing decontamination as primary treatment
›Wash all clothing and bedding
›Hot water cycle 60 degrees Celsius or higher
›High-heat drying cycle for at least 20 minutes
›Items not washable placed in sealed plastic bag for 2 weeks
›Lice cannot survive without human host beyond 1 to 2 weeks
›Body bathing
›Thorough bathing and hair washing
›Pharmacotherapy alone is insufficient without environmental hygiene
›Topical pediculicide for body lice if available
›Permethrin 1% cream or 5% cream to body and clothing
›Malathion 0.5% lotion as alternative
›First-line: permethrin 1% cream rinse or pyrethrins with piperonyl butoxide
›Apply to affected area
›Leave on 10 minutes then rinse
›Repeat at day 9 to 10
›Treat all affected hair-bearing areas including axillary hair and trunk
›Alternatives for pubic lice
›Malathion 0.5% lotion
›Apply 8 to 12 hours; repeat in 7 to 9 days if live lice persist
›Oral ivermectin 250 micrograms per kilogram
›Repeat at day 7 to 10
›Eyelash infestation (phthiriasis palpebrarum)
›Petroleum jelly (Vaseline) applied to lashes twice daily for 8 to 10 days
›Suffocates lice and nits; safe for ocular surface
›Manual removal with fine-toothed forceps
›Do NOT apply pediculicidal shampoos to eyes
Louse-borne systemic disease treatment
›Epidemic typhus (Rickettsia prowazekii)
›Doxycycline 100 mg PO or IV twice daily
›Duration: until afebrile for 48 to 72 hours (minimum 5 to 7 days)
›Class I recommendation; treatment of choice
›Chloramphenicol 500 mg IV every 6 hours as alternative
›Use only when doxycycline contraindicated
›Monitor for aplastic anemia
›Louse-borne relapsing fever (Borrelia recurrentis)
›Doxycycline 100 mg single oral dose or IV
›Single dose highly effective in louse-borne relapsing fever
›Repeat dosing not typically required
›Jarisch-Herxheimer reaction
›Occurs 2 to 8 hours after first antibiotic dose
›Rigors, high fever, hypotension, worsening illness
›Supportive management: fluids, antipyretics
›Pre-treatment with meptazinol or hydrocortisone may reduce severity
›Erythromycin 500 mg as alternative for doxycycline-contraindicated patients
›Trench fever (Bartonella quintana)
›Uncomplicated: doxycycline 200 mg PO daily for 4 weeks
›Plus gentamicin 3 mg per kg IV daily for first 14 days
›Bartonella endocarditis: prolonged therapy 6 weeks or longer
›Doxycycline 200 mg daily plus gentamicin 3 mg per kg daily for 14 days
›Cardiac surgery consultation if valve destruction
Environmental decontamination
›Head lice environmental measures
›Wash and dry bedding, clothing, and stuffed animals used in prior 48 hours
›Hot cycle: 60 degrees Celsius minimum
›High heat dry for 20 minutes
›Soak combs and brushes in hot water 60 degrees Celsius for 10 minutes
›Vacuum upholstered furniture and car seats
›Do NOT use fumigant sprays or pesticide foggers
›Not necessary; lice do not survive long off human host
›Health risk without clinical benefit
›Contact treatment guidance
›Only treat individuals with confirmed live lice
›Prophylactic treatment of uninfested household contacts not routinely recommended