Pressure redistribution and prevention bundle
›Offloading and repositioning
›Repositioning schedule
›High risk adults reposition at least every 4 hours
›Children and youth reposition more frequently than every 4 hours
›Head of bed minimization
›Shear reduction
›Aspiration risk balance
›Heel offloading
›Heel suspension device
›Pillow under calves with heels floating
›Wheelchair pressure relief
›Weight shifts every 15 to 30 minutes when able
›Limit sitting duration if ulcer on ischium or sacrum
›Support surfaces
›High specification foam mattress
›Baseline for established pressure injury
›Limited efficacy if repositioning absent
›Dynamic support surface
›Refractory pressure injury
›Inability to reposition adequately
›Seat cushion selection
›Pressure redistributing cushion
›Fit assessment to pelvis and posture
›Cleansing and moisture balance
›Cleansing fluid selection
›Normal saline
›Potable water when appropriate
›Avoidance of cytotoxic solutions for routine care
›Hydrogen peroxide routine avoidance
›Iodine routine avoidance on healthy granulation
›Moist wound healing principles
›Excess exudate control
›Desiccation avoidance
›Debridement selection
›Autolytic debridement
›Occlusive dressing approach
›Avoid in overt infection
›Mechanical debridement
›Low pressure irrigation
›Wet to dry routine avoidance
›Enzymatic debridement
›Collagenase use for slough
›Avoid with exposed tendon without protection
›Sharp or surgical debridement
›Extensive necrosis
›Rapid infection source control need
›Dressing selection by wound characteristics
›Foam dressing
›Moderate exudate
›Cushioning and protection
›Hydrocolloid dressing
›Low to moderate exudate
›Autolytic debridement support
›Alginate dressing
›Heavy exudate
›Bleeding control adjunct
›Hydrofiber dressing
›Heavy exudate
›Reduced maceration risk
›Antimicrobial dressing
›High bioburden concern
›Short course reassessment
›Negative pressure wound therapy
›Indications
›Stage 3 or stage 4 with depth
›Heavy exudate requiring management
›Contraindications
›Untreated osteomyelitis without plan
›Malignancy in wound bed
›Technique considerations
›Dead space fill
›Seal integrity monitoring
›When antibiotics are indicated
›Cellulitis around wound
›Expanding erythema
›Warmth and tenderness
›Deep soft tissue infection
›Abscess
›Fasciitis concern
›Osteomyelitis
›Bone culture guided therapy
›Surgical source control planning
›When antibiotics are not indicated
›Colonization without clinical infection
›Odor alone after cleansing
›Stable chronic drainage without cellulitis
›Superficial swab growth without infection signs
›Avoid antibiotic escalation based on swab alone
›Focus on offloading and wound bed prep
›Empiric antibiotics for severe infection
›Broad coverage strategy
›MRSA coverage for high risk
›Gram negative coverage for deep ulcers
›Anaerobe coverage for necrotic tissue
›Vancomycin IV
›Loading dose 20 to 25 mg per kg actual body weight for severe infection
›Maintenance 15 to 20 mg per kg every 8 to 12 hours
›Trough based monitoring per local protocol
›Renal dose adjustment
›Piperacillin tazobactam IV
›4.5 g every 6 to 8 hours
›Renal dose adjustment
›Extended infusion per local protocol when available
›Alternative for beta lactam allergy
›Vancomycin IV
›Same dosing framework
›Therapeutic drug monitoring
›Aztreonam IV
›2 g every 8 hours
›Renal dose adjustment
›Metronidazole IV or PO
›500 mg every 8 hours
›Anaerobe coverage
›Targeted antibiotics for mild cellulitis
›Nonpurulent cellulitis
›Cephalexin PO
›500 mg four times daily
›Typical duration 5 to 7 days
›Clindamycin PO
›300 to 450 mg three times daily
›C difficile risk counseling
›MRSA risk cellulitis
›Doxycycline PO
›100 mg twice daily
›Avoid in pregnancy
›Trimethoprim sulfamethoxazole PO
›1 to 2 double strength tablets twice daily
›Hyperkalemia risk monitoring
Pain and symptom management
›Analgesia ladder
›Acetaminophen PO
›650 mg every 6 hours as needed
›Maximum daily dose per local guidance
›Ibuprofen PO
›400 mg every 6 to 8 hours as needed
›Avoid in renal injury and GI bleeding risk
›Opioid for severe pain
›Morphine PO
›5 to 10 mg every 4 hours as needed
›Constipation prophylaxis
›Hydromorphone PO
›1 to 2 mg every 4 to 6 hours as needed
›Sedation monitoring
›Dressing change pain control
›Premedication timing
›Oral analgesic 30 to 60 minutes prior
›IV analgesic 10 to 20 minutes prior when inpatient
›Topical anesthetic consideration
›Lidocaine gel when appropriate
›Avoid on large surface area without supervision
Nutrition and metabolic optimization
›Nutritional support
›Protein goals
›Increased protein intake for healing
›Renal disease tailored protein plan
›Caloric adequacy
›Dietitian guided plan
›Enteral supplementation when intake poor
›Micronutrients
›Vitamin C adequacy
›Zinc supplementation only if deficiency or high risk
›Glycemic management
›Hyperglycemia control
›Basal bolus insulin inpatient when needed
›Sick day plan outpatient
Surgical and advanced therapies
›Source control procedures
›Incision and drainage
›Drainable abscess
›Culture collection from deep tissue
›Operative debridement
›Extensive eschar with infection
›Necrotizing infection concern
›Reconstruction planning
›Flap coverage evaluation
›Large stage 4 defects
›Recurrent ulcers despite optimization
›Pre flap prerequisites
›Offloading plan reliable
›Nutrition optimization underway
›Smoking cessation support