Approach to the Critical Patient

Immediate priorities

Airway and breathing threats

Circulation threats

Isolation and infection control priorities

Monitoring and targets

Monitoring bundle

Escalation triggers

Immediate consults

Consultation triggers

History

Exposure history

Epidemiologic risk

Symptom characterization

Classic symptom progression

Timeline and progression

Risk factors

Major exposure risks

Physical Exam

Vitals and general

Stability snapshot

General appearance

Head eyes ears nose throat and skin

Orofacial and mucosal findings

Skin findings

Abdomen and organ systems

Abdominal findings

Cardiovascular and volume status

PITFALLS

Diagnostic pitfalls

Differential Diagnosis

Life-threatening mimics

Immediate threats

Haematologic and metabolic emergencies

Common mimics

Tropical infectious diseases

Systemic infections

Marburg virus disease coding

ICD-10 classification

Laboratory Tests

Core diagnostic testing

Primary diagnostic test

Haematology and coagulation

Complete blood count

Coagulation studies

Metabolic and organ function

Electrolytes

Hepatic function

Renal function

Sepsis and inflammation markers

Lactate

Blood cultures

C-reactive protein and procalcitonin

Diagnostic Tests

Scoring Systems

Marburg severity and risk stratification

MRI

MRI role in Marburg virus disease

CT

CT imaging indications

Ultrasound

Point-of-care ultrasound applications

Disposition

Level of care selection

Mandatory isolation and admission

Transfer and specialist centre criteria

Transfer indications

Public health and discharge considerations

Public health notifications

Treatment

Infection control and supportive priorities

Infection control measures

Fluid resuscitation

Vasopressors and haemodynamic support

Vasopressor therapy

Antiviral and investigational therapeutics

Remdesivir (investigational in MVD)

MBP091 monoclonal antibody

No approved antiviral treatments for MVD currently

Haemorrhage and coagulopathy management

Thrombocytopenia and bleeding management

Secondary infection management

Empirical antibiotics for bacterial superinfection

Malaria co-treatment

Organ failure support

Renal replacement therapy

Mechanical ventilation

Special Populations

Pregnancy

Pregnancy-specific considerations

Geriatric

Older adult considerations

Pediatrics

Pediatric differences

Background

Epidemiology

Outbreak history and incidence

Pathophysiology

Viral biology

Disease mechanism

Therapeutic Considerations

Antiviral strategy rationale

Supportive care evidence base

Infection prevention and transmission

Patient Discharge Instructions

copy discharge instructions

Marburg virus disease discharge information

Sexual transmission precautions

General recovery guidance

Warning signs to return to emergency

Protecting your household

Follow-up plan

References

Guidelines and key sources

Guideline sources

Key clinical evidence

Coding standards

SymptomDx is an educational tool for medical professionals. It does not replace clinical judgment. Verify all clinical data and drug dosages with authoritative sources.