Ley EJ et al. Journal of Trauma and Acute Care Surgery 2020
Landmark trials
PREVENT CLOT trial (METRC consortium)
NEJM 2023; O'Toole RV et al.
Aspirin 81 mg BID noninferior to enoxaparin for 90-day death prevention
IMN vs external fixation outcomes
Testa G et al. Journal of Clinical Medicine 2019
Major complication 5.4% IMN vs 21.9% external fixation
Femoral nerve block in ED (Altunbas E et al.)
American Journal of Emergency Medicine 2025
FNB superior to IV fentanyl for pain control
FES incidence systematic review
Lempert M et al. Journal of Clinical Medicine 2021
1.7% incidence in modern era
Key references
Ricci WM et al. JAAOS 2009: intramedullary nailing current concepts
Greenhill DA and Herman MJ. JAAOS 2022: pediatric femoral shaft fracture treatment
Madhuri V et al. Cochrane Database 2014: interventions for pediatric femur fractures
Kanlic E and Cruz M. Orthopedics 2007: pediatric femur fracture treatment concepts
Kwon J and Coimbra R. J Trauma Acute Care Surg 2024: fat embolism syndrome review
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