›Apixaban and rivaroxaban: safe for surgery > 24 hours after last dose (low bleeding risk)
›Dabigatran: 48-72 hours if eGFR >= 50; longer if renal impairment
›No approved reversal agents for routine use; idarucizumab for dabigatran, andexanet alfa for factor Xa inhibitors if emergent
›Implant selection by fracture pattern
›Stable patterns (AO/OTA A1)
›Sliding hip screw (SHS)
›Dynamic compression at fracture site
›Lower implant cost than cephalomedullary nail
›Unstable patterns (AO/OTA A2, A3) — cephalomedullary nail (CMN)
›Short versus long nail based on subtrochanteric extension
›A3 and reverse obliquity patterns require long nail
›AAOS strong recommendation for CMN in unstable patterns
›Cephalomedullary nail reduces malrotation and varus collapse
›Anesthesia type
›Spinal versus general anesthesia
›No significant difference in 30-day mortality or ambulation at 60 days
›Spinal anesthesia associated with less postoperative cognitive dysfunction in some series
›Multimodal anesthesia with peripheral nerve block reduces intraoperative opioid requirement
Perioperative pharmacotherapy
›Antibiotic prophylaxis
›Cefazolin 2 g IV 1-2 hours preoperatively
›Repeat cefazolin 2 g IV if surgery > 3 hours or blood loss > 1500 mL
›Continue for 24 hours postoperatively
›Vancomycin 15 mg/kg IV if cephalosporin allergy or MRSA risk
›Infuse over 60 minutes to reduce infusion reactions
›Tranexamic acid (TXA)
›TXA 1 g IV at induction of anesthesia (strong recommendation)
›Reduces intraoperative and postoperative blood loss
›Reduces transfusion requirement
›Safe in most patients including those with renal impairment at standard doses
›Topical TXA 1.5-3 g (alternative or adjunct to IV route)
›VTE prophylaxis
›Chemoprophylaxis preferred over mechanical-only prophylaxis (ACCP and AAOS)
›Enoxaparin 40 mg SC daily (renal dose adjust if eGFR < 30: 20 mg daily)
›Start 12 hours postoperatively
›Continue for minimum 4 weeks
›Aspirin 81-325 mg daily (METRC trial: non-inferior to LMWH for VTE)
›Acceptable alternative in low-moderate risk patients
›Rivaroxaban 10 mg daily for 5 weeks (alternative DOAC)
›Mechanical prophylaxis (compression stockings, IPC devices)
›Use in addition to pharmacoprophylaxis
›Sole therapy only if pharmacoprophylaxis absolutely contraindicated
›Transfusion thresholds
›Restrictive strategy preferred
›Hgb < 80 g/L in asymptomatic, hemodynamically stable patients
›Hgb < 100 g/L if symptomatic anemia, active cardiac disease, or hemodynamic instability
›Transfuse packed red blood cells 1 unit at a time; reassess after each unit
›Delirium prevention
›Minimize opioid dose (nerve blocks reduce opioid need)
›Avoid benzodiazepines as first-line for agitation
›Non-pharmacologic: early mobilization, frequent reorientation, avoid restraints, optimize sleep
›Haloperidol 0.5-1 mg IV for severe agitation if non-pharmacologic measures fail
›Monitor QTc
›Early mobilization
›Weight-bearing as tolerated beginning day of or day after surgery
›Early mobilization (< 24 hours) improves functional outcomes
›Physical therapy and occupational therapy throughout admission
›Nutritional support
›Oral nutritional supplementation high-protein (>= 1.2 g/kg/day protein)
›Reduces infective complications by 50%, pressure ulcers, and hospital length of stay
›Calcium 800-1000 mg/day and vitamin D 800-1000 IU/day
›Osteoporosis secondary prevention
›Bisphosphonate initiation typically 2 weeks post-surgery
›Alendronate 70 mg PO weekly or zoledronic acid 5 mg IV annually
›DEXA scan referral within 3 months for formal osteoporosis assessment