›650 to 1000 mg PO every 6 hours
›Maximum 4 g per day; 2 g per day in hepatic impairment
›Short-course opioids for severe acute pain only
›Lowest effective dose shortest duration
›Reserve for grade III or combined injury perioperative use
Immobilization and bracing
›Grade I injury
›Elastic compression sleeve
›Permits range of motion
›Worn during activity
›Weight-bearing as tolerated
›No brace requirement in most cases
›Grade II injury
›Hinged knee brace
›Locked at 40 to 45 degrees for 2 to 3 weeks
›Progressive unlocking as pain and stability improve
›Crutches until pain-free gait achieved
›Grade III injury
›Long leg posterior splint or hinged knee brace
›Immobilization in extension initially if surgical planning
›Coordinated with orthopedic surgeon preference
›Non-weight-bearing pending surgical decision
›Early repair within 2 to 3 weeks for combined injuries
›Phase 1 (weeks 0 to 3) — acute
›Isometric quadriceps and hamstring sets
›No varus stress through knee
›Ankle pumps for venous stasis prevention
›Cryotherapy and elevation continue
›Pain-guided activity
›Phase 2 (weeks 3 to 8) — subacute
›Progressive isotonic strengthening
›Closed kinetic chain exercises
›Stationary bike with low resistance
›Range of motion restoration
›Goal full extension and 90 degrees flexion by week 6
›Proprioception training initiation
›Single-leg balance progression
›Phase 3 (weeks 8 to return to sport) — functional
›Sport-specific agility drills
›Lateral cutting and deceleration
›Return to sport typically 3 to 6 months for grade II
›Functional brace use during return to activity
›Provides proprioceptive and mechanical support
›ACEP Level C recommendation for functional bracing in knee ligament injuries
›Indications for operative repair
›Grade III LCL with combined PLC injury
›Early repair within 2 to 3 weeks strongly recommended
›Delayed treatment leads to worse outcomes
›Grade III in young active patients
›Nonoperative grade III shows high long-term laxity and osteoarthritis rates
›Surgical repair preferred for restoration of stability
›Combined multiligament injury
›Concurrent cruciate ligament reconstruction
›Anatomic reconstruction preferred for PLC
›Surgical options
›Primary repair
›Effective within 2 to 3 weeks of acute injury
›Ligament-to-bone healing possible in acute phase
›Anatomic reconstruction
›Modified Larson technique or fibular-based reconstruction
›Preferred for chronic or irreparable injuries
›In NFL athletes with isolated grade III LCL
›Nonoperative returned to play average 2 weeks vs. 14.5 weeks surgical
›Equivalent long-term outcomes reported
›Decision individualized to injury pattern and demands
›Peroneal nerve palsy management
›Initial observation
›Ankle-foot orthosis for foot drop
›Serial neurologic exams
›EMG/NCS at 3 to 6 weeks
›Axonotmesis pattern may recover over months
›Complete palsy prognosis poor with only 12% regaining function
›If no recovery by 3 to 6 months
›Neurolysis consideration
›Tendon transfer for functional restoration