›Maximum 2,000 mg per day in liver disease or alcohol use
›Alternative when NSAIDs contraindicated
›Acceptable as adjunct to NSAIDs
›Opioids
›Rarely indicated for isolated meniscal tear
›Reserve for severe acute pain when NSAIDs and acetaminophen inadequate
›If used, prescribe lowest effective dose for shortest duration
›2-3 days maximum; reassess before any extension
Adjunctive physical interventions
›Cryotherapy
›Ice packs or cold compression devices
›Reduces pain and swelling in first 72 hours
›Avoid direct skin contact (use cloth barrier)
›Knee immobilizer
›Indications: significant pain with ambulation, instability, or suspected displaced tear
›Not for long-term use in stable nondisplaced tears
›Crutches
›Partial weight-bearing as tolerated
›Full non-weight-bearing for locked knee pending surgical consultation
Conservative management (first-line for most tears)
›Physical therapy program
›AAOS Strong Recommendation: PT as first-line for nonobstructive meniscal tears
›Based on Level I evidence from multiple RCTs
›Neuromuscular exercises 1-2 times weekly
›Quadriceps strengthening
›Hamstring strengthening
›Balance and proprioception training
›Duration: minimum 3 months recommended before considering surgery
›ESCAPE trial evidence
›321 patients randomized to PT versus arthroscopic partial meniscectomy
›PT noninferior to surgery for knee function over 24 months
›Supports PT as primary management for nonobstructive tears (JAMA 2018)
›Activity modification
›Gradual return to activity as symptoms allow
›Avoid high-impact pivoting activities during acute phase
›Low-impact cross-training acceptable (cycling, swimming)
›Surgical indications
›Locked knee or displaced bucket-handle tear
›Prompt referral; surgery typically within days to weeks
›Meniscal root tears
›High OA progression risk if untreated
›Young active patient with reparable tear in vascularized zone
›Outer 10-30% of meniscus has blood supply from the periphery
›Early repair preserves meniscal tissue and protects against OA
›Failure of 4-6 weeks of conservative management
›Surgery within 6 months of symptom onset for best outcomes
›Arthroscopic partial meniscectomy
›Most common meniscal surgery performed
›Return to sport approximately 7-9 weeks
›Appropriate for irreparable tears in avascular zone
›Cochrane 2022: no benefit over conservative management for degenerative tears with OA
›Avoid in patients with pre-existing knee OA unless locked knee
›Evidence level: Class IIa recommendation based on RCT data
›Meniscal repair
›Return to sport approximately 5-6 months
›Longer recovery due to healing requirements
›Failure rate 14.8%
›Higher success when combined with ACL reconstruction
›Preferred over meniscectomy in young patients when technically feasible
›Requires vascularized peripheral zone tear for healing potential
Intra-articular injections
›Corticosteroid injection
›Not first-line in acute setting
›May mask symptoms and delay diagnosis
›Consider for older patients with degenerative tear and inflammatory flare
›Triamcinolone acetonide 40 mg or methylprednisolone 40-80 mg
›Hyaluronic acid injection
›Evidence limited; not recommended for acute traumatic tears
›May be considered for degenerative tears with concomitant OA