Nonpharmacologic first-line
›Core measures
›Education and reassurance
›Favorable natural history for uncomplicated acute low back pain
›Avoidance of routine imaging without red flags
›Activity and mobility
›Continue usual activities as tolerated
›Avoid prolonged bed rest
›Heat therapy
›Superficial heat wrap 15 to 20 minutes sessions
›Skin burn avoidance counseling
›Early movement program
›Walking program
›Gentle stretching within pain limits
›Physical therapy referral when needed
›Persistent functional limitation
›Recurrent episodes with poor self-management success
›NSAIDs
›Ibuprofen oral dosing
›Initiate 400 mg to 600 mg every 6 to 8 hours as needed
›Maximum 2400 mg per day for most patients
›Gastroprotection consideration in GI risk
›Naproxen oral dosing
›Initiate 250 mg to 500 mg twice daily as needed
›Maximum 1000 mg per day
›Longer half-life counseling
›Diclofenac oral dosing
›Initiate 50 mg three times daily as needed
›Maximum 150 mg per day
›Cardiovascular risk awareness
›NSAID contraindications and cautions
›CKD or dehydration risk
›Avoid or use lowest dose shortest course
›Serum creatinine review when indicated
›History of GI ulcer or GI bleeding
›Proton pump inhibitor co-therapy consideration
›Avoid if high risk without protection
›Heart failure or significant cardiovascular disease
›Avoid high dose prolonged courses
›Naproxen relative risk profile consideration
›Pregnancy third trimester
›Avoid due to fetal and ductal risk
›Obstetric guidance alignment
›Acetaminophen
›Oral dosing
›Initiate 650 mg every 6 hours as needed
›Alternate option 1000 mg every 8 hours as needed
›Maximum 3000 mg per day preferred outpatient ceiling
›Hepatic cautions
›Chronic liver disease
›Lower maximum daily dose
›Avoid combination products overuse
›Heavy alcohol use
›Lower maximum daily dose
›Counsel on overdose risk
›Topical agents
›Topical NSAID options
›Diclofenac gel to localized tender area
›Lower systemic exposure than oral
›Skin irritation monitoring
›Topical lidocaine
›Lidocaine patch 4 percent or 5 percent off-label for focal pain
›12 hours on then 12 hours off typical schedule
›Skin reaction monitoring
Muscle relaxants and adjuncts
›Skeletal muscle relaxants short course
›Cyclobenzaprine oral dosing
›Initiate 5 mg at bedtime
›Titrate to 5 mg three times daily if needed
›Maximum 10 mg three times daily
›Methocarbamol oral dosing
›Initiate 500 mg to 750 mg every 6 hours as needed
›Sedation counseling
›Avoid driving if impaired
›Tizanidine oral dosing
›Initiate 2 mg every 8 hours as needed
›Titrate in 2 mg increments
›Maximum 24 mg per day
›Adverse effects and cautions
›Sedation and falls risk
›Avoid in high fall risk patients
›Night dosing preference when possible
›Anticholinergic burden with cyclobenzaprine
›Avoid in older adults when possible
›Urinary retention risk
Opioids and restricted use
›Opioid avoidance as routine
›ACEP Level C guidance for acute low back pain discharge
›Nonopioid analgesics and nonpharmacologic therapies adequacy check before opioid prescription
›Opioids reserved for severe pain or pain refractory to other analgesics
›Lowest practical dose and limited duration
›CDC 2022 opioid guidance alignment for adults
›Lowest effective dose
›No longer than expected duration of severe pain
›Pediatric and adolescent caution
›Avoid initiating opioids for routine mechanical low back pain
›Follow local pediatric pain policies when unavoidable
Therapies to avoid in uncomplicated mechanical pain
›Low value or harmful options
›Routine imaging without red flags
›Increased incidental findings and downstream interventions
›No outcome benefit in uncomplicated acute pain
›Prolonged bed rest
›Delayed recovery association
›Deconditioning risk
›Routine systemic corticosteroids
›Limited benefit for nonspecific low back pain
›Adverse effect risk
›Benzodiazepines for back pain
›Sedation and dependence risk
›No clear functional benefit in uncomplicated cases