›Propofol for short procedures
›Ketamine as alternative
›Fentanyl with midazolam combination
›Indication
›True fracture-dislocations
›Failed or inadequate hematoma block
›Multimodal oral and IV analgesia
›Acetaminophen
›1 g every 6 hours
›Maximum 4 g per day
›NSAIDs
›Short-term low-dose use
›Avoid prolonged use over fracture-healing concern
›Opioids
›Reserve for severe pain
›Use judiciously and short course
Antibiotics and prophylaxis
›Surgical prophylaxis
›Cefazolin
›2 g IV within 1 hour of incision
›3 g IV if weight 120 kg or greater
›Open fracture coverage
›Add gentamicin for higher-grade open injury
›Tetanus prophylaxis as indicated
›VTE prophylaxis
›LMWH
›Enoxaparin 40 mg SQ daily
›Lower VTE incidence in operatively treated ankle fractures
›Continue through immobilization and non-weight-bearing
›Aspirin alternative
›81 mg PO twice daily
›Reasonable per PREVENT CLOT data for isolated orthopedic injury
›Risk-stratified omission
›TRiP(cast) score under 7 may forgo prophylaxis
›Shared decision for bleeding risk
Definitive surgical management
›Open reduction internal fixation
›Standard of care
›Lateral malleolus plate and screws
›Medial malleolus screws or tension band
›Posterior malleolus screws or buttress plate
›Posterior malleolus fixation
›Fragment greater than 25 percent traditional indication
›Fix smaller fragments when step-off greater than 1 mm
›Syndesmotic fixation
›Intraoperative stress testing
›Fix if unstable
›Two-stage strategy
›Temporizing external fixation
›For significant soft-tissue swelling
›Delayed ORIF typically at 7 to 14 days
›Outcomes
›Mean FAOS 93 of 100 reported
›Low complication rates
›Timing and soft tissue
›Wrinkle test
›Operate once swelling subsides
›Skin wrinkling indicates readiness
›Complication awareness
›Step-off greater than 1 mm raises osteoarthritis odds 3.9
›Highest reoperation rate for fusion or replacement hazard ratio 2.07