›Low-energy mechanisms (simple falls, sports, stepping off curb) predominate
›High-energy mechanisms (motor vehicle collisions, crush injuries) produce more severe patterns
›Athletic injuries increasingly recognized in elite and recreational athletes
›Medicolegal significance
›Among most common causes of litigation against emergency physicians and radiologists
›20% misdiagnosis rate contributes to delayed care and poor outcomes
›Delayed diagnosis associated with worse functional outcomes and post-traumatic arthritis
Pathophysiology
›Anatomy of the tarsometatarsal joint complex
›Lisfranc joint: Tarsometatarsal articulations between all five metatarsal bases and tarsal bones
›Medial cuneiform articulates with first and second metatarsal bases
›Middle cuneiform articulates with second metatarsal
›Lateral cuneiform articulates with third metatarsal
›Cuboid articulates with fourth and fifth metatarsal bases
›Lisfranc ligament complex
›Interosseous Lisfranc ligament: Between medial cuneiform and base of second metatarsal
›Strongest ligament in the complex
›Primary stabilizer of the medial column
›Dorsal Lisfranc ligament: Weaker, often injured first
›Plantar Lisfranc ligament: Strongest component; disruption indicates severe instability
›No intermetatarsal ligament between first and second metatarsal — Lisfranc ligament only connection
›Injury mechanism
›Axial compression through plantarflexed foot transmits force along metatarsal shafts to bases
›Twisting forces create rotational stress across TMT joint complex
›Spectrum of injury: Ligamentous sprain to complete fracture-dislocation
›Fleck sign represents avulsion of Lisfranc ligament at second metatarsal base
›Complications
›Post-traumatic arthritis: Most common long-term sequela
›Chronic midfoot pain and instability
›Arch collapse and flatfoot deformity
›Compartment syndrome: Tight fascial compartments of the foot susceptible after injury
›Neurovascular injury to dorsalis pedis artery and deep peroneal nerve
Therapeutic Considerations
›Nonoperative versus operative management evidence
›Purely ligamentous Lisfranc injuries have worse outcomes with nonoperative management if unstable
›Stable, nondisplaced injuries (confirmed on MRI): Nonoperative treatment with good outcomes
›Any diastasis 2 mm or greater is indication for operative fixation
›Operative technique considerations
›Bridge plating trending preferred over transarticular screws to avoid iatrogenic cartilage damage
›Suture button fixation advantages
›Preserves native joint motion
›Lower reoperation rates for ligamentous injuries
›Emerging evidence supports equivalence or superiority to screw fixation
›Primary arthrodesis vs ORIF debate
›Primary arthrodesis: Post-traumatic arthritis rate 2.8% vs 17.3% with ORIF
›Primary arthrodesis: Reoperation rate 14.7% vs 38.3% with ORIF
›Primary arthrodesis most appropriate for medial column injuries
›Return to sport evidence
›Over 90% of athletes return to sport after appropriate treatment
›Stable injuries: Return to sport 6 to 10 weeks
›Operative cases: Return to full activity 4 to 6 months
›2024 International Foot and Ankle Sports Consensus provides athlete-specific guidance
›Post-traumatic arthritis prevention
›Anatomic reduction reduces risk of post-traumatic arthritis
›Even with optimal treatment some degree of arthritis common after high-energy injuries
›Patient counseling about long-term prognosis and potential arthritis essential
11Patient Discharge Instructions/pdi32
copy discharge instructions
›Diagnosis and injury overview
›You have been diagnosed with a Lisfranc injury (midfoot injury involving the tarsometatarsal joints)
›This injury can range from a ligament sprain to a fracture-dislocation of the midfoot
›Your injury was evaluated and determined to be stable at this time
›Activity restrictions
›Do not bear any weight on your injured foot
›Use crutches or a knee scooter for all movement
›Keep your foot elevated above the level of your heart as much as possible
›Apply ice wrapped in a cloth for 20 minutes several times daily for the first 48 hours
›Splint and cast care
›Keep your splint or boot dry at all times
›Do not remove or adjust the splint
›If the splint feels too tight, return immediately to the emergency department — do not wait
›Medications
›Take ibuprofen or naproxen with food as directed for pain
›Take acetaminophen as directed if NSAIDs are not sufficient or not tolerated
›Do not take more than the prescribed dose of any medication
›Follow-up appointment
›You must see an orthopedic surgeon within 5 to 7 days — this appointment is mandatory
›Repeat weightbearing X-rays may be taken at your follow-up to confirm the injury has not shifted
›Return to the emergency department immediately if you experience any of these warning signs
›Severe or increasing pain that is not controlled by medications or elevation
›Numbness, tingling, or inability to move your toes
›Toes turning pale, blue, or cold
›Worsening swelling that does not improve with elevation
›Splint or boot feels increasingly tight
›Any open wound, drainage, or signs of infection (redness, warmth, foul odor)
›Recovery expectations
›Stable injuries typically heal in 6 to 10 weeks with proper immobilization
›Some injuries require surgery — your orthopedic surgeon will make this determination
›Even with proper treatment, some long-term stiffness or discomfort in the midfoot is possible
›Smoking significantly impairs bone healing — smoking cessation is strongly advised
12References/r24
Guidelines and key sources
›McDermott A, Repanshek Z, Koyfman A, Long B. High Risk and Low Incidence Diseases: Lisfranc Injury. American Journal of Emergency Medicine. 2024. PMID 39276688
›Comprehensive emergency medicine review; primary grounding source for ED management and disposition
›Lau S, Bozin M, Thillainadesan T. Lisfranc Fracture Dislocation: A Review of a Commonly Missed Injury of the Midfoot. Emergency Medicine Journal. 2017. PMID 27013521
›Clinical review of mechanism, exam findings, imaging, and treatment
›Siddiqui NA, Galizia MS, Almusa E, Omar IM. Evaluation of the Tarsometatarsal Joint Using Conventional Radiography, CT, and MR Imaging. Radiographics. 2014. PMID 24617695
›Detailed imaging review including fleck sign, diastasis criteria, and multimodal imaging
›Juto H, Mukka S, Wolf O, Moller M. Epidemiology, Classification, and Treatment of 2084 Lisfranc Injuries. Injury. 2025. PMID 39626601
›Large Swedish Fracture Register epidemiological study
›Semelsberger SD, Boggiano VJ, Webber K, et al. Diagnostic Evaluation and Nonoperative Management of Lisfranc Injuries in Athletes. Knee Surgery Sports Traumatology Arthroscopy. 2025. PMID 41451696
›Athletic population management and return to sport evidence
›Poutoglidou F, van Groningen B, McMenemy L, Elliot R, Marsland D. Acute Lisfranc Injury Management. Bone and Joint Journal. 2024. PMID 39615511
›Current management guidelines including ORIF vs arthrodesis evidence
›O'Connor KP, Tackett LB, Riehl JT. Primary Arthrodesis Versus ORIF for Acute Lisfranc Injuries: Systematic Review and Meta-Analysis. Archives of Orthopaedic and Trauma Surgery. 2024. PMID 39680239
›Post-traumatic arthritis 2.8% vs 17.3% and reoperation 14.7% vs 38.3% data
Imaging and classification sources
›Expert Panel on Musculoskeletal Imaging, Gorbachova T, Chang EY, et al. ACR Appropriateness Criteria: Acute Trauma to the Foot. Journal of the American College of Radiology. 2020
›ACR guidance on appropriate imaging modality selection
›Tamir E, Essa A, Levi A, et al. Lisfranc Injury Diagnosis: Diagnostic Reliability of New Radiographic Signs Using 3D CT. Clinical Orthopaedics and Related Research. 2023. PMID 37078895
›Nunley JA, Vertullo CJ. Classification, Investigation, and Management of Midfoot Sprains: Lisfranc Injuries in the Athlete. American Journal of Sports Medicine. 2002. PMID 12435655
›Nunley-Vertullo Classification Stage I to III original publication
›Herscovici D, Scaduto JM. The Lisfranc Jut: A Physical Finding of Subtle Lisfranc Injuries. Injury. 2021. PMID 33413925
›Description of Lisfranc jut sign for subtle injury detection
›Balboni JM, Levine AR, Boggiano VJ, et al. Operative Treatment of Lisfranc Injuries in Elite Athletes: 2024 International Foot and Ankle Sports Consensus. Knee Surgery Sports Traumatology Arthroscopy. 2026. PMID 41649218
›International consensus on operative management in athletes
SymptomDx is an educational tool for medical professionals. It does not replace clinical judgment. Verify all clinical data and drug dosages with authoritative sources.