›Outpatient regimens
›No comorbidities and no MRSA or Pseudomonas risk
›Amoxicillin oral
›1 g three times daily
›Typical duration 5 days with clinical stability criteria
›Doxycycline oral
›100 mg twice daily
›Avoid in pregnancy
›Azithromycin oral
›Use only if local pneumococcal macrolide resistance low
›500 mg day 1
›250 mg daily days 2-5
›Comorbidities
›Amoxicillin clavulanate oral
›875 mg 125 mg twice daily
›Alternative 2 g 125 mg twice daily extended release if available
›Plus azithromycin oral
›500 mg day 1
›250 mg daily days 2-5
›Plus doxycycline oral alternative to macrolide
›100 mg twice daily
›Cefuroxime oral alternative beta-lactam
›500 mg twice daily
›Plus azithromycin oral
›500 mg day 1
›250 mg daily days 2-5
›Levofloxacin oral monotherapy
›750 mg daily
›QT prolongation and tendinopathy risk context
›Moxifloxacin oral monotherapy
›400 mg daily
›Avoid with significant QT risk
›Inpatient non-ICU regimens
›Beta-lactam plus macrolide
›Ceftriaxone IV
›1-2 g daily
›Plus azithromycin IV or oral
›500 mg daily
›Ampicillin sulbactam IV
›1.5-3 g every 6 hours
›Plus azithromycin IV or oral
›500 mg daily
›Beta-lactam plus doxycycline alternative
›Ceftriaxone IV
›1-2 g daily
›Plus doxycycline IV or oral
›100 mg twice daily
›Respiratory fluoroquinolone monotherapy
›Levofloxacin IV or oral
›750 mg daily
›Moxifloxacin IV or oral
›400 mg daily
›ICU regimens
›Beta-lactam plus macrolide
›Ceftriaxone IV
›2 g daily
›Plus azithromycin IV
›500 mg daily
›Cefotaxime IV alternative
›2 g every 8 hours
›Plus azithromycin IV
›500 mg daily
›Beta-lactam plus fluoroquinolone alternative
›Ceftriaxone IV
›2 g daily
›Plus levofloxacin IV
›750 mg daily
›MRSA coverage when indicated
›Vancomycin IV
›15-20 mg/kg per dose
›Typical interval every 8-12 hours based on renal function
›AUC-guided monitoring per local protocol
›Linezolid IV or oral
›600 mg twice daily
›Thrombocytopenia risk with prolonged therapy
›Pseudomonas coverage when indicated
›Cefepime IV
›2 g every 8 hours
›Piperacillin tazobactam IV
›4.5 g every 6 hours
›Meropenem IV
›1 g every 8 hours
›Plus azithromycin IV
›500 mg daily
›Plus levofloxacin IV alternative
›750 mg daily
Timing, duration, and de-escalation
›Antimicrobial stewardship
›Early administration
›Severe CAP or shock within 1 hour
›Nonsevere CAP without shock within 3 hours
›De-escalation strategy
›Narrow to identified pathogen and susceptibilities
›Stop MRSA or Pseudomonas agents if risk low and tests negative
›Negative MRSA nasal PCR supports stopping anti-MRSA in many settings
›Duration guidance
›Minimum 5 days for most uncomplicated CAP
›Clinical stability criteria for stop
›Afebrile 48-72 hours
›HR <= 100 per minute
›RR <= 24 per minute
›SBP >= 90 mmHg
›SpO2 >= 90% or PaO2 >= 60 mmHg on room air or baseline
›Normal mental status baseline
›Oral intake adequate
›Extended duration triggers
›MRSA pneumonia
›Pseudomonas pneumonia
›Lung abscess or necrotizing pneumonia
›Empyema
›Respiratory support
›Oxygen therapy
›Nasal cannula escalation to face mask based on SpO2 targets
›HFNC for high oxygen requirement with tachypnea
›NIV for COPD with hypercapnia and acidosis when appropriate
›Bronchodilators for reactive component
›Salbutamol inhaled
›4-8 puffs MDI with spacer every 20 minutes for 1 hour as needed
›Nebulized alternative per local protocol
›Fluids and hemodynamics
›Crystalloid resuscitation for hypoperfusion
›Balanced crystalloids preferred by many protocols
›Reassess after each bolus
›Vasopressors for persistent hypotension
›Norepinephrine infusion
›Start 0.05-0.1 micrograms/kg/min
›Titrate every 2-5 minutes to MAP >= 65 mmHg
›Typical ceiling individualized by response and adverse effects
›Vasopressin adjunct
›0.03 units/min fixed dose for refractory shock
›Fever and pain control
›Acetaminophen oral or IV
›650-1000 mg every 6 hours as needed
›Maximum 3000 mg per day typical conservative limit
›NSAID use individualized
›Renal and GI risk context
›Corticosteroids
›Not routine for nonsevere CAP
›Consider for refractory septic shock
›Hydrocortisone IV
›50 mg every 6 hours
›COPD exacerbation overlap
›Prednisone oral
›40 mg daily for 5 days
›Pleural space management
›Diagnostic thoracentesis for moderate or large effusion
›pH and glucose and LDH pleural analysis per protocol
›Empyema management
›Early drainage plus antibiotics
›Surgical consultation for loculated disease