Resuscitation and hemorrhage control
›Blood product resuscitation
›Massive transfusion protocol
›Early activation in suspected major bleeding
›Balanced component therapy per institutional protocol
›Calcium replacement
›Calcium chloride IV
›1 g IV
›Repeat dosing guided by ionized calcium
›Calcium gluconate IV
›3 g IV
›Alternative if peripheral access only
›Temperature management
›Active warming to prevent coagulopathy
›Warmed fluids and blood products
›Antifibrinolytic therapy
›Tranexamic acid
›If within 3 hours of major trauma and suspected significant bleeding
›Initiate 1 g IV over 10 minutes
›Follow with 1 g IV over 8 hours
›Avoid initiation beyond 3 hours after injury due to harm signal in trauma literature
Analgesia and supportive care
›Analgesia plan
›Opioid options
›Fentanyl IV
›25-50 micrograms IV
›Repeat every 5-10 minutes to effect
›Monitor for respiratory depression
›Hydromorphone IV
›0.2-0.5 mg IV
›Repeat every 10-15 minutes to effect
›Longer duration caution in older adults
›Non-opioid adjuncts
›Acetaminophen PO or IV
›1000 mg
›Maximum 4000 mg per 24 hours
›Lower maximum in liver disease
›NSAID use
›Avoid if active bleeding concern
›Consider if bleeding controlled and renal function adequate
›Gastroprotection if high risk
›Regional analgesia
›Serratus anterior plane block
›Consider with multiple rib fractures
›Improved ventilation via pain control
›Coordinate with anesthesia or trained provider
Anticoagulant and antiplatelet reversal
›Reversal framework for life-threatening bleeding
›Vitamin K antagonist
›PCC dosing per INR and weight
›Institutional protocol dosing
›Concurrent vitamin K 10 mg IV
›Repeat INR monitoring
›Direct thrombin inhibitor
›Idarucizumab for dabigatran
›5 g IV total
›Two 2.5 g doses
›Rebound anticoagulation monitoring
›Factor Xa inhibitor
›PCC consideration when life-threatening bleeding
›Institutional protocol dosing
›Anti-factor Xa guided decisions if available
›Thrombosis risk discussion
Definitive hemorrhage control
›Operative management triggers
›Thoracotomy indications
›Initial chest tube output >1500 mL
›Suggests major vascular injury
›Immediate surgical control need
›Ongoing output >200 mL/hour for 2-4 hours
›Persistent bleeding despite drainage
›Operative exploration need
›Retained hemothorax management
›Early VATS
›Persistent pleural collection after tube
›Infection risk reduction
›Improved lung re-expansion
›Intrapleural fibrinolytics
›Consider in select non-operative candidates
›Higher bleeding risk consideration in trauma
›Specialist-guided decision