Digoxin toxicity

Abdominal aortic aneurysm Acute coronary syndrome (NSTEMI)Acute coronary syndrome (STEMI)Acute decompensated heart failure Acute limb ischemia Acute mesenteric ischemia Aortic dissection Aortic stenosis Atrial fibrillation and flutter Bradyarrhythmia and heart block Cardiac arrest Deep vein thrombosis Myocarditis Pericarditis Pulmonary embolism Stable angina Superficial thrombophlebitis Superior vena cava syndrome Supraventricular tachycardia Syncope (cardiogenic)Unstable angina Ventricular tachycardia

Acute bronchitis Acute respiratory failure Aspiration pneumonia Asthma exacerbation Bronchiolitis Community-acquired pneumonia COVID-19 pneumonia COPD exacerbation Croup Croup (laryngotracheobronchitis)Epiglottitis Hemothorax Hospital-acquired pneumonia Pleural effusion Pneumothorax (traumatic)Pulmonary contusion Spontaneous pneumothorax

Bell's palsy Benign paroxysmal positional vertigo Brain abscess Cauda equina syndrome Cervical radiculopathy Concussion (mild traumatic brain injury)Encephalitis Guillain-Barré syndrome Hemorrhagic stroke (intracerebral)Ischemic stroke Lumbar radiculopathy Malignant spinal cord compression Migraine Peripheral neuropathy (acute)Retropharyngeal abscess Schizophrenia (acute exacerbation)Seizure (breakthrough:known epilepsy)Seizure (first-time)Spinal cord injury Status epilepticus Subarachnoid hemorrhage Tension headache Transient ischemic attack Traumatic brain injury (moderate-severe)Vestibular neuritis Viral meningitis

Acute appendicitis Acute cholecystitis Acute diverticulitis Acute pancreatitis Anal fissure Choledocholithiasis and cholangitis Clostridioides difficile colitis Gastritis Gastroenteritis (viral and bacterial)Gastroesophageal reflux disease Incarcerated or strangulated hernia Inflammatory bowel disease flare Large bowel obstruction Lower GI hemorrhage Peptic ulcer disease Perforated viscus Small bowel obstruction Upper GI hemorrhage

Acute prostatitis Acute urinary retention Ectopic pregnancy Epididymitis Orchitis Ovarian torsion Paraphimosis Pelvic inflammatory disease Priapism Pyelonephritis Renal laceration Ruptured ovarian cyst Testicular torsion Tubo-ovarian abscess Urinary tract infection (uncomplicated)Urolithiasis (renal colic)Vaginal bleeding (non-pregnant)

Acute sinusitis Acute tonsillitis Acute upper respiratory infection Animal bite Bacterial meningitis Cellulitis Conjunctivitis (bacterial)Dental abscess Endocarditis Febrile neutropenia Fournier gangrene Hand-foot-mouth disease Hepatitis (acute)Herpes zoster HIV-related illness Human bite Impetigo Infected diabetic foot ulcer Infectious mononucleosis Influenza Necrotizing fasciitis Osteomyelitis Otitis externa Parasitic infection Periorbital cellulitis Peritonsillar abscess Scabies Sepsis Septic arthritis Spontaneous bacterial peritonitis Tick-borne illness (Lyme disease)Tinea infection Tuberculosis Viral exanthem Wound infection

Achilles tendon rupture ACL and mceniscus tear Ankle fracture Ankle sprain Burn Calcaneus fracture Cervical spine fracture Clavicle fracture Dental avulsion Distal radius fracture Drowning Elbow fracture and dislocation Electrical injury Facial bone fracture Facial laceration Femur fracture Fingertip amputation Forearm fracture (radius and ulna)Frostbite Hand:finger laceration Heat exhaustion Heat stroke Hip fracture Humeral shaft fracture Knee dislocation Knee sprain Lightning injury Mandible fracture Metacarpal fracture Metatarsal fracture Muscle strain Nasal fracture Non-accidental trauma Orbital fracture Patella fracture Phalanx fracture (finger)Proximal humerus fracture Pulmonary contusion Rib fracture Rotator cuff tear (acute traumatic)Scalp laceration Scaphoid fracture Shoulder dislocation Skull fracture Splenic laceration Sternal fracture Supracondylar pediatric fracture Tendon laceration (hand:wrist)Thoracic and lumbar spine fracture Tibia:fibula fracture Tibial plateau fracture Toe fracture Traumatic epistaxis Traumatic hyphema

Acetaminophen toxicity Alcohol intoxication Alcohol withdrawal Anticholinergic toxicity Anticoagulant overdose Benzodiazepine overdose Benzodiazepine:sedative overdose Beta-blocker and calcium channel blocker toxicity Carbon monoxide poisoning Caustic ingestion Digoxin toxicity Drug eruption Foreign body ingestion Opioid intoxication Opioid overdose Opioid withdrawal Organophosphate Salicylate toxicity Serotonin syndrome Stimulant intoxication (cocaine, methamphetamine)Tricyclic antidepressant overdose

Acute anxiety Acute psychosis Agitation:behavioral emergency Bipolar disorder Conversion disorder Major depressive episode Neuroleptic malignant syndrome Suicidal ideation and attempt

Acute low back pain (mechanical)Bursitis Cervical radiculopathy Costochondritis Gout (acute)Lumbar radiculopathy Pseudogout Tendinitis

Acute eczema (Eczema acute flare)Allergic contact dermatitis Erythema multiforme Henoch-Schönlein purpura Pressure injury Psoriasis (acute flare)Stevens-Johnson syndrome Toxic epidermal necrolysis Urticaria (acute)

Envenomation (snake, spider, insect)High-altitude illness Hypothermia

Acute chest syndrome Coagulopathy Hyperviscosity syndrome Sickle cell crisis (vaso-occlusive)Symptomatic anemia Thrombocytopenia (severe)Tumor lysis syndrome

Bronchiolitis Croup Emergency delivery Febrile seizure Kawasaki disease Neonatal jaundice Neonatal sepsis Nursemaid's elbow Pediatric fever 0 to 28 days Pediatric fever 29 to 60 days Pediatric fever 61 to 90 days Pyloric stenosis Slipped capital femoral epiphysis Intussusception

Adrenal crisis Diabetic ketoacidosis Hypercalcemia Hyperosmolar hyperglycemic state Hypertensive emergency Hypertensive urgency Hypoglycemia Myasthenia gravis crisis Myxedema coma Severe hyperkalemia Severe hyponatremia Thyroid storm

Acute laryngitis Acute otitis media Acute pharyngitis Cerumen impaction Epistaxis (anterior)Nasal foreign body Otitis externa Tympanic membrane perforation

Acute angle-closure glaucoma Central retinal artery occlusion Chemical eye injury Corneal abrasion Corneal ulcer Globe rupture Ocular foreign body Orbital cellulitis Retinal detachment

Hyperemesis gravidarum Painful vaginal bleeding in pregnancy Placenta previa Placental abruption Preeclampsia:eclampsia Preterm labor Threatened:inevitable:incomplete abortion

Anaphylaxis Angioedema Cannabis-induced hyperemesis

Digoxin toxicity

Clinical Assessment Checklist

Browse categories and answer follow-up questions to refine your symptom profile.

Immediate priorities

Immediate stabilization

Airway patency and aspiration risk

If vomiting and reduced consciousness then airway protection

Breathing and oxygenation

Oxygen for hypoxemia

Circulation and perfusion

Large bore IV access times 2

Continuous cardiac monitoring

Defibrillator pads in place

Rapid 12 lead ECG

Repeat ECG after any rhythm change

Point of care glucose

Hypoglycemia correction

High risk features

Ventricular tachycardia or ventricular fibrillation

Urgent digoxin specific Fab

High grade AV block

Urgent digoxin specific Fab

Hemodynamic instability

Urgent digoxin specific Fab

Hyperkalemia in suspected cardiac glycoside poisoning

Urgent digoxin specific Fab

Team activation

Poison centre or medical toxicology consult early

Early antidote coordination and dosing strategy

Cardiology consult for unstable conduction disease

Temporary pacing planning

Evidence and guidelines

Digoxin specific Fab for life threatening cardiac glycoside poisoning

AHA focused update supports administration in life threatening poisoning Class I

Evidence base heterogeneous and dosing varies by region

When ACEP policy absent use expert consensus framework ACEP Level C

Monitoring and targets

Monitoring bundle

Continuous ECG rhythm and rate trends

Intermittent 12 lead ECG for evolving block or ectopy

Frequent blood pressure

Arterial line for shock or vasopressors

Strict input output

Urinary catheter for shock or severe toxicity

Physiologic targets

Adequate perfusion

Mentation improving

Capillary refill improving

Urine output improving

Electrolyte targets

Potassium 4.0 to 5.0 mmol/L

Magnesium at upper normal range

Initial antidote readiness

Digoxin specific Fab readiness

Immediate pharmacy notification

Stock check and rapid delivery

Reconstitution and infusion plan

Anaphylaxis preparedness

Post Fab monitoring plan

Rebound toxicity surveillance

Medical Disclaimer

SymptomDx is an educational tool for medical professionals. It does not replace clinical judgment. Verify all clinical data and drug dosages with authoritative sources.

Last Reviewed: January 15, 2026 by SymptomDX Medical Team

SymptomDx is an educational tool for medical professionals. It does not replace clinical judgment. Verify all clinical data and drug dosages with authoritative sources.

← Management Protocols

Home Management ProtocolsDigoxin toxicity

Digoxin toxicity

Clinical Assessment Checklist

Browse categories and answer follow-up questions to refine your symptom profile.

Immediate priorities

Immediate stabilization

Airway patency and aspiration risk

If vomiting and reduced consciousness then airway protection

Breathing and oxygenation

Oxygen for hypoxemia

Circulation and perfusion

Large bore IV access times 2

Continuous cardiac monitoring

Defibrillator pads in place

Rapid 12 lead ECG

Repeat ECG after any rhythm change

Point of care glucose

Hypoglycemia correction

High risk features

Ventricular tachycardia or ventricular fibrillation

Urgent digoxin specific Fab

High grade AV block

Urgent digoxin specific Fab

Hemodynamic instability

Urgent digoxin specific Fab

Hyperkalemia in suspected cardiac glycoside poisoning

Urgent digoxin specific Fab

Team activation

Poison centre or medical toxicology consult early

Early antidote coordination and dosing strategy

Cardiology consult for unstable conduction disease

Temporary pacing planning

Evidence and guidelines

Digoxin specific Fab for life threatening cardiac glycoside poisoning

AHA focused update supports administration in life threatening poisoning Class I

Evidence base heterogeneous and dosing varies by region

When ACEP policy absent use expert consensus framework ACEP Level C

Monitoring and targets

Monitoring bundle

Continuous ECG rhythm and rate trends

Intermittent 12 lead ECG for evolving block or ectopy

Frequent blood pressure

Arterial line for shock or vasopressors

Strict input output

Urinary catheter for shock or severe toxicity

Physiologic targets

Adequate perfusion

Mentation improving

Capillary refill improving

Urine output improving

Electrolyte targets

Potassium 4.0 to 5.0 mmol/L

Magnesium at upper normal range

Initial antidote readiness

Digoxin specific Fab readiness

Immediate pharmacy notification

Stock check and rapid delivery

Reconstitution and infusion plan

Anaphylaxis preparedness

Post Fab monitoring plan

Rebound toxicity surveillance

Medical Disclaimer

SymptomDx is an educational tool for medical professionals. It does not replace clinical judgment. Verify all clinical data and drug dosages with authoritative sources.

Last Reviewed: January 15, 2026 by SymptomDX Medical Team

SymptomDx is an educational tool for medical professionals. It does not replace clinical judgment. Verify all clinical data and drug dosages with authoritative sources.

← Management Protocols

Home Management ProtocolsDigoxin toxicity