›Repeat based on perfusion
›Blood product strategy for severe hemorrhage
›Packed red blood cells transfusion if symptomatic anemia
›Ongoing bleeding with instability
›Hemoglobin thresholds individualized
›Massive transfusion protocol activation triggers
›Refractory hypotension
›Rapid hemoglobin decline
›Large hemoperitoneum with shock
›Coagulation reversal when relevant
›Warfarin associated bleeding
›Prothrombin complex concentrate per protocol
›Dose by INR and weight
›Rapid administration
›Vitamin K IV 5 mg to 10 mg once
›Slower onset than PCC
›DOAC associated life threatening bleeding
›Local reversal protocol
›Andexanet alfa for factor Xa inhibitors if available
›Idarucizumab for dabigatran if available
Procedural and operative management
›Nonoperative management for stable patients
›Observation period with serial exams
›Pain trajectory improving
›Stable vitals
›Repeat hemoglobin timing
›4 to 6 hours if moderate free fluid
›Sooner if worsening symptoms
›Operative management triggers
›Persistent hemodynamic instability
›Despite fluids and transfusion
›Suspected ongoing hemorrhage
›Expanding hemoperitoneum
›Falling hemoglobin
›Diagnostic uncertainty with peritonitis
›Laparoscopy consideration
›Surgical options
›Laparoscopy preferred when feasible
›Hemostasis
›Cystectomy if needed
›Laparotomy consideration
›Massive hemoperitoneum
›Inability to stabilize
›Antibiotics
›PID concern regimen initiation
›Ceftriaxone IM 500 mg once
›1000 mg once if weight at least 150 kg
›Allergy alternative pathway
›Doxycycline PO 100 mg twice daily for 14 days
›Pregnancy contraindication
›Photosensitivity counseling
›Metronidazole PO 500 mg twice daily for 14 days
›Avoid alcohol