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Symptom
dx.
Clinical Reference
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Clinical Reference
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Practical Skills
ECG
Interpretation guide
POCUS
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Acute Respiratory Distress Syndrome (ARDS)
Cardiovascular Presentations
Abdominal aortic aneurysm
Acute coronary syndrome (NSTEMI)
Acute coronary syndrome (STEMI)
Acute decompensated heart failure
Acute limb ischemia
Acute mesenteric ischemia
Aortic dissection
Aortic stenosis
Atrial fibrillation and flutter
Bradyarrhythmia and heart block
Cardiac arrest
Deep vein thrombosis
Myocarditis
Pericarditis
Pulmonary embolism
Stable angina
Superficial thrombophlebitis
Superior vena cava syndrome
Supraventricular tachycardia
Syncope (cardiogenic)
Unstable angina
Ventricular tachycardia
Respiratory Presentations
Acute bronchitis
Acute respiratory failure
Aspiration pneumonia
Asthma exacerbation
Bronchiolitis
Community-acquired pneumonia
COVID-19 pneumonia
COPD exacerbation
Croup
Croup (laryngotracheobronchitis)
Epiglottitis
Hemothorax
Hospital-acquired pneumonia
Pleural effusion
Pneumothorax (traumatic)
Pulmonary contusion
Spontaneous pneumothorax
Neurological Presentations
Bell's palsy
Benign paroxysmal positional vertigo
Brain abscess
Cauda equina syndrome
Cervical radiculopathy
Concussion (mild traumatic brain injury)
Encephalitis
Guillain-Barré syndrome
Hemorrhagic stroke (intracerebral)
Ischemic stroke
Lumbar radiculopathy
Malignant spinal cord compression
Migraine
Peripheral neuropathy (acute)
Retropharyngeal abscess
Schizophrenia (acute exacerbation)
Seizure (breakthrough:known epilepsy)
Seizure (first-time)
Spinal cord injury
Status epilepticus
Subarachnoid hemorrhage
Tension headache
Transient ischemic attack
Traumatic brain injury (moderate-severe)
Vestibular neuritis
Viral meningitis
Gastrointestinal Presentations
Acute appendicitis
Acute cholecystitis
Acute diverticulitis
Acute pancreatitis
Anal fissure
Choledocholithiasis and cholangitis
Clostridioides difficile colitis
Gastritis
Gastroenteritis (viral and bacterial)
Gastroesophageal reflux disease
Incarcerated or strangulated hernia
Inflammatory bowel disease flare
Large bowel obstruction
Lower GI hemorrhage
Peptic ulcer disease
Perforated viscus
Small bowel obstruction
Upper GI hemorrhage
Genitourinary and Reproductive Presentations
Acute prostatitis
Acute urinary retention
Ectopic pregnancy
Epididymitis
Orchitis
Ovarian torsion
Paraphimosis
Pelvic inflammatory disease
Priapism
Pyelonephritis
Renal laceration
Ruptured ovarian cyst
Testicular torsion
Tubo-ovarian abscess
Urinary tract infection (uncomplicated)
Urolithiasis (renal colic)
Vaginal bleeding (non-pregnant)
Infectious Disease Presentations
Acute sinusitis
Acute tonsillitis
Acute upper respiratory infection
Animal bite
Bacterial meningitis
Cellulitis
Conjunctivitis (bacterial)
Dental abscess
Endocarditis
Febrile neutropenia
Fournier gangrene
Hand-foot-mouth disease
Hepatitis (acute)
Herpes zoster
HIV-related illness
Human bite
Impetigo
Infected diabetic foot ulcer
Infectious mononucleosis
Influenza
Necrotizing fasciitis
Osteomyelitis
Otitis externa
Parasitic infection
Periorbital cellulitis
Peritonsillar abscess
Scabies
Sepsis
Septic arthritis
Spontaneous bacterial peritonitis
Tick-borne illness (Lyme disease)
Tinea infection
Tuberculosis
Viral exanthem
Wound infection
Trauma Presentations
Achilles tendon rupture
ACL and mceniscus tear
Ankle fracture
Ankle sprain
Burn
Calcaneus fracture
Cervical spine fracture
Clavicle fracture
Dental avulsion
Distal radius fracture
Drowning
Elbow fracture and dislocation
Electrical injury
Facial bone fracture
Facial laceration
Femur fracture
Fingertip amputation
Forearm fracture (radius and ulna)
Frostbite
Hand:finger laceration
Heat exhaustion
Heat stroke
Hip fracture
Humeral shaft fracture
Knee dislocation
Knee sprain
Lightning injury
Mandible fracture
Metacarpal fracture
Metatarsal fracture
Muscle strain
Nasal fracture
Non-accidental trauma
Orbital fracture
Patella fracture
Phalanx fracture (finger)
Proximal humerus fracture
Pulmonary contusion
Rib fracture
Rotator cuff tear (acute traumatic)
Scalp laceration
Scaphoid fracture
Shoulder dislocation
Skull fracture
Splenic laceration
Sternal fracture
Supracondylar pediatric fracture
Tendon laceration (hand:wrist)
Thoracic and lumbar spine fracture
Tibia:fibula fracture
Tibial plateau fracture
Toe fracture
Traumatic epistaxis
Traumatic hyphema
Toxicologic Presentations
Acetaminophen toxicity
Alcohol intoxication
Alcohol withdrawal
Anticholinergic toxicity
Anticoagulant overdose
Benzodiazepine overdose
Benzodiazepine:sedative overdose
Beta-blocker and calcium channel blocker toxicity
Carbon monoxide poisoning
Caustic ingestion
Digoxin toxicity
Drug eruption
Foreign body ingestion
Opioid intoxication
Opioid overdose
Opioid withdrawal
Organophosphate
Salicylate toxicity
Serotonin syndrome
Stimulant intoxication (cocaine, methamphetamine)
Tricyclic antidepressant overdose
Psychiatric Presentations
Acute anxiety
Acute psychosis
Agitation:behavioral emergency
Bipolar disorder
Conversion disorder
Major depressive episode
Neuroleptic malignant syndrome
Suicidal ideation and attempt
Musculoskeletal and Rheumatologic Presentations
Acute low back pain (mechanical)
Bursitis
Cervical radiculopathy
Costochondritis
Gout (acute)
Lumbar radiculopathy
Pseudogout
Tendinitis
Dermatology Presentations
Acute eczema (Eczema acute flare)
Allergic contact dermatitis
Erythema multiforme
Henoch-Schönlein purpura
Pressure injury
Psoriasis (acute flare)
Stevens-Johnson syndrome
Toxic epidermal necrolysis
Urticaria (acute)
Environmental and Exposure Presentations
Envenomation (snake, spider, insect)
High-altitude illness
Hypothermia
Hematologic and Oncologic Presentations
Acute chest syndrome
Coagulopathy
Hyperviscosity syndrome
Sickle cell crisis (vaso-occlusive)
Symptomatic anemia
Thrombocytopenia (severe)
Tumor lysis syndrome
Pediatric-Specific Presentations
Bronchiolitis
Croup
Emergency delivery
Febrile seizure
Kawasaki disease
Neonatal jaundice
Neonatal sepsis
Nursemaid's elbow
Pediatric fever 0 to 28 days
Pediatric fever 29 to 60 days
Pediatric fever 61 to 90 days
Pyloric stenosis
Slipped capital femoral epiphysis
Intussusception
Endocrine and Metabolic Presentations
Adrenal crisis
Diabetic ketoacidosis
Hypercalcemia
Hyperosmolar hyperglycemic state
Hypertensive emergency
Hypertensive urgency
Hypoglycemia
Myasthenia gravis crisis
Myxedema coma
Severe hyperkalemia
Severe hyponatremia
Thyroid storm
ENT and Maxillofacial Presentations
Acute laryngitis
Acute otitis media
Acute pharyngitis
Cerumen impaction
Epistaxis (anterior)
Nasal foreign body
Otitis externa
Tympanic membrane perforation
Ophthalmologic Presentations
Acute angle-closure glaucoma
Central retinal artery occlusion
Chemical eye injury
Corneal abrasion
Corneal ulcer
Globe rupture
Ocular foreign body
Orbital cellulitis
Retinal detachment
Obstetric Presentations
Hyperemesis gravidarum
Painful vaginal bleeding in pregnancy
Placenta previa
Placental abruption
Preeclampsia:eclampsia
Preterm labor
Threatened:inevitable:incomplete abortion
Systemic and Miscellaneous Presentations
Anaphylaxis
Angioedema
Cannabis-induced hyperemesis
Acute Respiratory Distress Syndrome (ARDS)
POCUS
Procedures
Calculators
Resuscitation
ECG Guide
Back
Clinical Assessment Checklist
Browse categories and answer follow-up questions to refine your symptom profile.
Approach to the Critical Patient
Immediate priorities
Airway and oxygenation threats
▶
Refractory hypoxemia
▶
SpO2 < 88% despite high-flow oxygen
Escalating FiO2 requirement
PaO2/FiO2 ratio severity
▶
PaO2/FiO2 <= 100 mmHg severe ARDS
Mortality approximately 45% in severe disease
Work of breathing failure
▶
Respiratory rate often > 30 per minute
Accessory muscle use and fatigue
If unable to oxygenate on HFNC or NIV, proceed to intubation
▶
Rapid sequence intubation preparation
Target SpO2 88% to 95% avoiding hyperoxia
Circulation and shock threats
▶
Hemodynamic instability
▶
SBP < 90 mmHg
MAP < 65 mmHg
Sepsis as common precipitant
▶
Suspected infection with organ dysfunction
Lactate >= 2 mmol/l
If septic shock, broad spectrum antibiotics within 1 hour
▶
Class I recommendation
Source control planning
Acute cor pulmonale risk
▶
Elevated pulmonary vascular resistance
RV strain from high ventilator pressures
Diagnostic anchoring
▶
Berlin definition pattern
▶
Acute onset within 7 days of insult
Bilateral opacities not fully explained by effusion or atelectasis
Exclusion of hydrostatic edema
▶
Not fully explained by cardiac failure or fluid overload
Echocardiography when no clear ARDS risk factor
If indolent onset beyond 7 days, consider ARDS mimics
▶
Organizing pneumonia
Acute interstitial lung disease exacerbation
Monitoring and targets
Ventilator and gas exchange monitoring
▶
Continuous pulse oximetry
▶
SpO2 target 88% to 95%
Avoid hyperoxia
Plateau and driving pressure tracking
▶
Plateau pressure <= 30 cm H2O
Driving pressure < 15 cm H2O
Serial arterial blood gas
▶
PaO2/FiO2 trend
PaCO2 with permissive hypercapnia tolerance
Escalation triggers
▶
Rising oxygen requirement despite optimization
▶
Prone positioning consideration
ECMO referral evaluation
Persistent hypotension after resuscitation
▶
Norepinephrine initiation
ICU level care
Refractory hypoxemia on lung-protective ventilation
▶
VV-ECMO center transfer
Rescue vasodilator therapy
Immediate consults
Consultation triggers
▶
Severe or refractory ARDS
▶
Critical care at bedside
ECMO center notification
Undifferentiated etiology
▶
Infectious disease for atypical pathogens
Rheumatology when vasculitis suspected
Source control need
▶
Surgery for intra-abdominal sepsis
Interventional drainage planning
History
Presentation pattern
Core syndrome
▶
Rapidly progressive dyspnea
▶
Evolution over hours to days
Tachypnea
Hypoxemia refractory to supplemental oxygen
▶
Cyanosis
Inability to lie flat
Onset timing
▶
Within 7 days of known clinical insult
New or worsening respiratory symptoms
Important negatives
▶
Distinguishing from cardiogenic edema
▶
Absence of orthopnea
Absence of paroxysmal nocturnal dyspnea
No prior CHF exacerbations
▶
No baseline peripheral edema
No known low ejection fraction
Precipitant and risk factors
Pulmonary precipitants
▶
Pneumonia
▶
Most common cause
Bacterial and viral
Aspiration of gastric contents
▶
Witnessed aspiration event
Depressed mental status
Inhalation injury
▶
Smoke inhalation
Vaping or e-cigarette use EVALI
Extrapulmonary precipitants
▶
Non-pulmonary sepsis
▶
Intra-abdominal source
Urinary source
Severe trauma
▶
Pulmonary contusion
Traumatic brain injury
Pancreatitis
▶
Systemic inflammatory response
Third spacing
Massive transfusion
▶
Transfusion-related acute lung injury
Multiple product exposure
Modifiable and host risk factors
▶
Alcohol use disorder
▶
Independent risk factor for ARDS
Impaired alveolar clearance
Cigarette smoking
▶
Ambient air pollution exposure
Occupational inhalants
Excessive crystalloid resuscitation
▶
OR 1.19 per additional liter in first 6 hours
Trauma resuscitation context
Collateral and key clues
Collateral history
▶
Witnesses to aspiration event
▶
Timeline of symptom onset
Medication or substance ingestion
Recent procedures
▶
Esophagectomy
Cardiothoracic surgery
Family and genetic context
▶
Genetic susceptibility suggested
▶
Small attributable risk per polymorphism
Haptoglobin Hp-2 variant in sepsis
Physical Exam
Vitals and general
Stability snapshot
▶
Respiratory rate
▶
Often > 30 per minute
Rising trend as fatigue marker
Oxygen saturation
▶
SpO2 < 90% on room air
Refractory to supplemental oxygen
Blood pressure
▶
SBP < 90 mmHg if concurrent shock
MAP < 65 mmHg
General appearance
▶
Increased work of breathing
▶
Accessory muscle use
Nasal flaring and intercostal retractions
Mental status
▶
Hypoxic agitation
Septic encephalopathy
Pulmonary and cardiac exam
Pulmonary findings
▶
Bilateral crackles
▶
Diffuse distribution
Fine rales
Decreased breath sounds
▶
Consolidation correlation
Dependent atelectasis
Cardiovascular findings
▶
Cardiogenic edema discriminators
▶
JVD assessment
S3 gallop and peripheral edema
Acute cor pulmonale signs
▶
RV heave
Loud P2
PITFALLS
Under-recognition
▶
ARDS missed at diagnosis
▶
Approximately 40% unrecognized in LUNG SAFE
Only 31.4% received initial lung-protective ventilation
Coexisting heart failure
▶
Present in up to one-third of ARDS patients
Does not exclude ARDS
Extrapulmonary clues
▶
Skin findings overlooked
▶
Mottling in shock
Petechiae of fat embolism syndrome
Abdominal source missed
▶
Tenderness of pancreatitis
Intra-abdominal sepsis as precipitant
Differential Diagnosis
Life threats and close mimics
Must-exclude diagnosis
▶
Cardiogenic pulmonary edema
▶
Elevated BNP and S3 gallop
Echocardiography is key discriminator
Decompensated heart failure
▶
JVD and peripheral edema
Response to diuresis
Infectious and hemorrhagic mimics
▶
Bilateral pneumonia without ARDS
▶
May not meet oxygenation criteria
Lobar pattern
Diffuse alveolar hemorrhage
▶
Hemoptysis with dropping hemoglobin
Bloody return on serial BAL
Acute eosinophilic pneumonia
▶
Peripheral eosinophilia
BAL eosinophils > 25%
Subacute and immune mimics
▶
Organizing pneumonia
▶
Subacute course
Drug-induced pneumonitis exposure
Hypersensitivity pneumonitis
▶
Antigen exposure history
BAL lymphocytosis
Pulmonary vasculitis
▶
ANCA-associated systemic features
Anti-GBM disease
Pulmonary alveolar proteinosis
▶
Crazy paving on CT
Milky BAL
Coding and special presentations
Diagnostic coding
▶
ARDS
▶
ICD-10 J80
SNOMED CT acute respiratory distress syndrome disorder
Acute respiratory failure with hypoxia
▶
ICD-10 J96.01
Underlying cause coded separately
Special presentations
▶
Acute chest syndrome
▶
Sickle cell disease context
Pain crisis association
Acute interstitial lung disease exacerbation
▶
Known ILD baseline
Ground-glass with honeycombing
Laboratory Tests
Gas exchange and severity
Arterial blood gas
▶
PaO2/FiO2 ratio defines severity
▶
Mild 200 to 300 mmHg
Moderate 100 to 200 mmHg
Severe <= 100 mmHg
Acid-base status
▶
PaCO2 retention with fatigue
Lactic acidosis with hypoperfusion
SpO2/FiO2 ratio
▶
Non-invasive alternative when ABG unavailable
▶
SpO2/FiO2 <= 315 correlates with ARDS criteria
Valid when SpO2 <= 97%
2024 Global Definition application
▶
Resource-limited settings
High-flow nasal oxygen pathway
Etiology and organ function
Infection workup
▶
Complete blood count
▶
Leukocytosis with infection
Eosinophilia suggesting eosinophilic pneumonia
Blood cultures
▶
All patients without obvious sterile insult
Prior to antibiotics when feasible
Procalcitonin and CRP
▶
Bacterial infection support
Not a rule-out test
Respiratory cultures and viral panel
▶
Sputum or tracheal aspirate
Multiplex respiratory PCR
Organ function and discriminators
▶
Basic metabolic panel
▶
Renal function and electrolytes
Lactate for tissue perfusion
BNP or NT-proBNP
▶
Helps differentiate cardiogenic edema
Interpreted with echocardiography
Coagulation studies
▶
DIC screening in sepsis
Baseline before anticoagulation
Advanced and atypical workup
Bronchoalveolar lavage
▶
Atypical pathogen identification
▶
PJP and Legionella and Nocardia
Sensitivity approximately 58% for infectious etiology
Non-infectious patterns
▶
Eosinophilic pneumonia
Diffuse alveolar hemorrhage and alveolar proteinosis
Autoimmune panel
▶
When no infectious cause identified
▶
ANA and ANCA
Anti-GBM antibodies
Diagnostic Tests
Scoring Systems
Berlin definition
▶
Diagnostic criteria
▶
Acute onset within 7 days
Bilateral opacities on imaging
PaO2/FiO2 on PEEP >= 5 cm H2O
Not fully explained by cardiac failure
Severity strata
▶
Mild PaO2/FiO2 200 to 300 mmHg mortality approximately 27%
Moderate PaO2/FiO2 100 to 200 mmHg mortality approximately 32%
Severe PaO2/FiO2 <= 100 mmHg mortality approximately 45%
2024 New Global Definition
▶
Expanded modalities
▶
High-flow nasal oxygen >= 30 L/min pathway
SpO2/FiO2 ratio inclusion
Lung ultrasound acceptance
Resource stratified application
▶
Non-intubated category
Limited-resource settings
Physiologic and prognostic indices
▶
Driving pressure
▶
Plateau pressure minus PEEP
Target < 15 cm H2O
Independently predicts mortality
Mechanical power
▶
Integrates ventilator variables
Marker of ventilator-induced lung injury risk
MRI
MRI chest role
▶
Limited acute utility
▶
Availability constraints
Motion artifact in critically ill
Problem-solving indications
▶
Characterizing complex masses
Suspected malignancy masquerading as infiltrate
Contraindications
▶
Hemodynamic instability
Non-compatible implants
CT
CT chest indications
▶
Characterization and mimics
▶
Gold standard for opacity characterization
Identifies effusions masses and ILD
When CXR equivocal
▶
High clinical suspicion with unclear film
Failure to improve on therapy
Recruitability and source
▶
Quantifies recruitable lung
Identifies intra-abdominal source
Contrast considerations
▶
Renal function assessment
▶
eGFR review
Hydration planning
Allergy history
▶
Prior contrast reaction
Premedication protocol
Evidence and guidance
▶
CT for diagnostic uncertainty
▶
ACEP Level C recommendation
Clinical deterioration trigger
Ultrasound
Lung ultrasound
▶
B-line pattern
▶
>= 3 B-lines per intercostal space
Multiple bilateral fields
Practical advantages
▶
Portable and radiation-free
Repeatable at bedside
Limitations
▶
Cannot distinguish cardiogenic from noncardiogenic edema by B-lines alone
Operator dependent
Accepted in 2024 Global Definition
Echocardiography
▶
Exclude hydrostatic edema
▶
When no clear ARDS risk factor present
LV systolic function estimate
RV assessment
▶
Acute cor pulmonale identification
RV dilation and septal flattening
Disposition
Level of care selection
ICU admission
▶
All established ARDS
▶
No floor-level management
No outpatient management
Need for ventilatory support
▶
Intubation and mechanical ventilation
HFNC with rising requirement
Shock physiology
▶
Vasopressor requirement
Rising lactate despite resuscitation
ECMO center transfer
▶
Severe refractory disease
▶
PaO2/FiO2 < 80 mmHg
Refractory to prone positioning and lung-protective ventilation
Early referral timing
▶
Before multi-organ failure
Coordinated mobile ECMO when available
Step-down and consultation
Step-down criteria
▶
Resolving mild ARDS
▶
Weaning from ventilatory support
Stable oxygenation on low FiO2
Spontaneous breathing trial readiness
▶
FiO2 <= 0.5
PEEP <= 8 cm H2O
Specialist consultation triggers
▶
Pulmonary and critical care
▶
All cases
Ventilator strategy optimization
Infectious disease
▶
Atypical or refractory infections
Immunocompromised host
Surgery and rheumatology
▶
Source control when needed
Autoimmune etiology suspected
Treatment
Initial stabilization and oxygenation
Airway and oxygen targets
▶
Oxygenation goal
▶
Target SpO2 88% to 95%
Avoid hyperoxia
Non-invasive support trial
▶
High-flow nasal oxygen
NIV in selected patients with monitoring
If unable to oxygenate on HFNC or NIV, intubate
▶
Rapid sequence intubation
Lung-protective settings from outset
Lung-protective ventilation
Ventilator strategy
▶
Tidal volume
▶
4 to 8 mL/kg predicted body weight
Target 6 mL/kg predicted body weight
Strong recommendation
Pressure limits
▶
Plateau pressure <= 30 cm H2O
Driving pressure < 15 cm H2O
PEEP strategy
▶
PEEP >= 5 cm H2O
Higher PEEP for moderate-to-severe ARDS
Without routine recruitment maneuvers
Recruitment maneuvers
▶
Prolonged recruitment recommended against
Strong recommendation
Permissive hypercapnia
▶
Tolerate elevated PaCO2
▶
Maintain pH generally > 7.20
Prioritize low tidal volume
Cautions
▶
Avoid with raised intracranial pressure
Avoid with severe pulmonary hypertension
Prone positioning
Prone positioning protocol
▶
Indication
▶
Moderate-to-severe ARDS PaO2/FiO2 < 150 mmHg
Strong recommendation for severe ARDS
Duration
▶
>= 12 to 16 hours per day
Daily sessions until improvement
Combined strategy benefit
▶
Low tidal volume plus prone positioning
Greatest mortality reduction
Monitoring during proning
▶
Pressure injury surveillance
Endotracheal tube and line security
Pharmacotherapy
Corticosteroids
▶
Moderate-to-severe ARDS within 14 days
▶
Dexamethasone 20 mg IV daily for 5 days
Then dexamethasone 10 mg IV daily for 5 days
Avoid initiation past 14 days as may worsen outcomes
Monitoring
▶
Glycemic control
Secondary infection surveillance
Neuromuscular blockade
▶
Early severe ARDS with refractory hypoxemia
▶
Cisatracurium intermittent boluses preferred over continuous infusion
Limit to <= 48 hours
Indication specifics
▶
Ventilator dyssynchrony
Deep sedation prerequisite
Treat the underlying cause
▶
Infection source
▶
Broad-spectrum antibiotics for suspected infection
De-escalate with culture data
Source control
▶
Drainage of intra-abdominal sepsis
Surgical intervention when indicated
Fluid management and supportive care
Conservative fluid strategy
▶
Net balance target
▶
Net neutral-to-negative once off vasopressors
Aggressive diuresis improves ventilator-free days
Cautions
▶
Avoid hypoperfusion
Monitor renal function during diuresis
Supportive bundle
▶
VTE prophylaxis
▶
Subcutaneous heparin or LMWH unless contraindicated
Mechanical prophylaxis if bleeding risk
Stress ulcer prophylaxis
▶
PPI or H2 blocker
Reassess need with enteral feeding
Nutrition and sedation
▶
Early enteral nutrition within 24 to 48 hours
Sedation titrated to ventilator synchrony
Daily spontaneous breathing trials when FiO2 <= 0.5 and PEEP <= 8 cm H2O
Rescue therapies for refractory hypoxemia
Inhaled pulmonary vasodilators
▶
Inhaled nitric oxide
▶
Transient oxygenation improvement
No proven mortality benefit
Inhaled epoprostenol
▶
Rescue oxygenation adjunct
Monitor for hypotension
VV-ECMO
▶
Selected severe refractory ARDS
▶
Refractory to conventional therapy
Transfer to ECMO center
Candidate considerations
▶
Reversible underlying process
Absence of major contraindications
Special Populations
Pregnancy
Pregnancy considerations
▶
Physiologic vulnerability
▶
Reduced functional residual capacity
Increased oxygen consumption
Oxygenation goals
▶
Maintain maternal SpO2 >= 95% when feasible
Fetal monitoring when viable gestation
Ventilation adjustments
▶
Account for chronic respiratory alkalosis of pregnancy
Left lateral tilt to relieve aortocaval compression
Medication and delivery planning
▶
Corticosteroids per maternal indication
Multidisciplinary obstetric and critical care coordination
Geriatric
Older adult features
▶
Higher mortality
▶
Reduced physiologic reserve
Frequent comorbidity burden
Diagnostic overlap
▶
Coexisting heart failure common
Careful volume assessment
Medication risk
▶
Renal dosing adjustment
Delirium minimization sedation strategy
Goals of care
▶
Early advance directive review
Shared decision-making on ECMO candidacy
Pediatrics
Pediatric ARDS differences
▶
PALICC definition
▶
Oxygenation index used rather than PaO2/FiO2
Oxygen saturation index when ABG unavailable
Weight-based ventilation
▶
Tidal volume 5 to 8 mL/kg predicted body weight
Lower for poor compliance
Etiology differences
▶
Viral pneumonia common
RSV and influenza precipitants
Escalation thresholds
▶
HFNC and NIV before intubation
Early ECMO referral for refractory cases
Background
Epidemiology
Frequency and burden
▶
ICU prevalence
▶
Approximately 10% of ICU admissions
Approximately 24% of mechanically ventilated patients
Mortality range
▶
In-hospital mortality 27% mild to 45% severe
Median ventilator days 5 to 9 in survivors
Recognition gap
▶
Approximately 40% unrecognized at diagnosis in LUNG SAFE
Only 31.4% received initial lung-protective ventilation
Pathophysiology
Mechanisms
▶
Diffuse alveolar damage
▶
Increased alveolar-capillary permeability
Protein-rich noncardiogenic edema
Phase progression
▶
Exudative phase with hyaline membranes
Proliferative and fibrotic phases
Gas exchange failure
▶
Intrapulmonary shunt
Ventilation-perfusion mismatch
Secondary injury pathways
▶
Ventilator-induced lung injury
Acute cor pulmonale from elevated pulmonary vascular resistance
Therapeutic Considerations
Lung-protective principles
▶
Minimize ventilator-induced lung injury
▶
Low tidal volume reduces overdistension
Driving pressure limitation
Open lung strategy balance
▶
Adequate PEEP to limit atelectrauma
Avoid prolonged recruitment maneuvers
Phenotype-directed care
▶
Hyperinflammatory versus hypoinflammatory subphenotypes
▶
Differential treatment responses
Emerging biomarker stratification
Conservative fluid strategy
▶
Net negative balance shortens ventilator days
Balance against perfusion
Limited-benefit therapies
▶
Immunonutrition
▶
No consistent benefit in ARDS
Omega-3 and antioxidant supplementation not routine
Inhaled vasodilators
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Oxygenation only without mortality benefit
Reserve as rescue
Patient Discharge Instructions
copy discharge instructions
Copy
ARDS survivor recovery plan
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Recovery is gradual over weeks to months
Pulmonary rehabilitation as recommended
Continue prescribed medications until reviewed
Attend all scheduled follow-up appointments
Expected long-term effects
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Reduced exercise tolerance and muscle weakness
Memory and concentration difficulty
Mood changes including anxiety or low mood
Persistent breathlessness improving over time
Warning signs to return to ER
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Worsening shortness of breath
New fever or chills
Oxygen desaturation if using home oximeter
Chest pain
Blue lips or face
Sudden functional decline or confusion
Follow up
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Primary care follow-up after discharge
Pulmonary function testing at 3 to 6 months
Earlier reassessment if symptomatic
Mental health support if persistent distress
References
Guidelines and key sources
Guideline sources
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ATS clinical practice guideline on management of ARDS 2024
ATS ESICM SCCM mechanical ventilation guideline 2017
Surviving Sepsis Campaign international guidelines
Landmark evidence
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New Global Definition of ARDS 2024
LUNG SAFE epidemiology study in 50 countries
Network meta-analysis of protective ventilation strategies
Coding standards
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ICD-10 J80 acute respiratory distress syndrome
SNOMED CT acute respiratory distress syndrome disorder concept
SymptomDx is an educational tool for medical professionals. It does not replace clinical judgment. Verify all clinical data and drug dosages with authoritative sources.
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Management Protocols
Acute Respiratory Distress Syndrome (ARDS)