›Intraperitoneal rupture mechanism
›Sudden intravesical pressure rise
›Distended bladder subjected to compressive force
›Dome is thinnest and most mobile bladder wall segment
›Classic mechanism
›Lap belt or steering wheel compression of lower abdomen against full bladder
›Intraperitoneal extravasation of urine into free peritoneal space
›Consequences
›Urinary peritonitis develops from chemical irritation
›Peritoneal reabsorption of urine causes pseudo-AKI and electrolyte derangements
›Hyperkalemia and hyponatremia from bidirectional solute transfer
›Extraperitoneal rupture mechanism
›Pelvic fracture fragment laceration
›Direct laceration of anterolateral bladder wall by bone fragment
›Pubic rami fractures most commonly responsible
›Shear forces from pelvic ring disruption
›Ligamentous and bladder wall avulsion from displacement
›Perivesical space fills with blood and urine mixture
›Extravasation pattern
›Urine confined to perivesical space and pelvic extraperitoneal fat
›May track along fascial planes to scrotum, perineum, or anterior abdominal wall
›Spontaneous rupture pathophysiology
›Bladder wall weakening combined with overdistension
›Radiation fibrosis impairs wall compliance and vascularity
›Neurogenic dysfunction impairs the urge-to-void reflex allowing severe overdistension
›Pressure-volume relationship
›Normal bladder accommodates 400-600 mL at low pressure
›Impaired compliance causes pressure rise at lower volumes
›Dome rupture occurs at intravesical pressures exceeding wall tensile strength
›Pseudo-AKI mechanism
›Reverse peritoneal dialysis phenomenon
›Urea and creatinine from urinary ascites reabsorbed across peritoneum
›Serum creatinine rises proportionally to volume of intraperitoneal urine
›Electrolyte derangements
›Potassium reabsorbed causing hyperkalemia
›Sodium diluted by osmotic water movement causing hyponatremia
›Rapid normalization within 24-48 hours after bladder repair and drainage
Therapeutic Considerations
›Operative versus nonoperative decision framework
›Intraperitoneal rupture always requires surgery
›No evidence supports nonoperative management for intraperitoneal injuries
›Strong recommendation per EAST, AUA, ACS, and WSES-AAST guidelines
›Uncomplicated extraperitoneal rupture primarily nonoperative
›2.4% failure rate with catheter drainage alone
›Follow-up cystography confirms healing before catheter removal
›Complicated extraperitoneal rupture requires surgery
›Bladder neck injuries require operative repair to preserve continence
›Concurrent injuries that require operative exploration drive decision
›Timing of repair
›Immediate repair for intraperitoneal rupture
›Delay worsens peritonitis and metabolic derangements
›Creatinine and potassium normalize within 48 hours of successful repair
›Damage control approach in hemodynamically unstable polytrauma
›Temporary suprapubic catheter with urinary diversion
›Definitive repair deferred until patient stabilized
›Elective repair considerations
›Complex anatomy patients benefit from planned urology subspecialty involvement
›Neobladder or augmentation repairs require experienced surgeon
›Anticoagulation reversal
›Warfarin reversal for urgent surgery
›Vitamin K 10 mg IV plus 4-factor prothrombin complex concentrate 25-50 units per kg
›Target INR less than 1.5 before elective repair
›Direct oral anticoagulant reversal
›Dabigatran reversal with idarucizumab 5g IV
›Factor Xa inhibitor reversal with andexanet alfa per weight-based protocol
›Antiplatelet considerations
›Aspirin generally continued perioperatively unless bleeding is severe
›P2Y12 inhibitors held 5-7 days if elective setting allows