Antibiotic regimens for peritonitis or sepsis
›Empiric broad-spectrum coverage
›Piperacillin-tazobactam IV
›4.5 g IV every 6 hours
›Extended infusion 4.5 g over 4 hours every 8 hours per local protocol
›Renal dose adjustment required
›Meropenem IV for high-resistance risk or severity
›1 g IV every 8 hours
›500 mg IV every 8 hours for renal impairment
›Add vancomycin if MRSA risk factors
›15-20 mg/kg IV every 8-12 hours
›AUC-guided monitoring preferred
›Flexible sigmoidoscopy
›First-line therapy for uncomplicated sigmoid volvulus
›Successful in 60-95% of cases
›ASCRS strong recommendation
›Prerequisites for safe endoscopy
›No peritoneal signs
›Hemodynamically stable
›No CT evidence of ischemia or perforation
›Procedure considerations
›Minimal air insufflation to reduce perforation risk
›Identify point of torsion
›Advance scope past twist carefully
›After successful detorsion
›Place rectal decompression tube
›Decompression tube reduces immediate recurrence
›Keep in place 24-48 hours
›Endoscopic failure triggers
›Inability to pass torsion point
›Dark or necrotic mucosa on endoscopy
›Immediate surgical escalation required
›Operative approach selection
›Emergent sigmoid resection for complicated volvulus
›Peritonitis, perforation, failed detorsion, ischemia
›Resect non-viable bowel
›Hartmann procedure
›End colostomy and closure of rectal stump
›Preferred in high-risk patients
›Sepsis, acidosis, coagulopathy, high ASA class
›Mortality 5-7%
›Primary anastomosis
›Considered in stable lower-risk patients
›Anastomotic leak rate approximately 4.7%
›Mortality approximately 3.4%
›Elective sigmoid colectomy during index admission
›Strongly recommended by ASCRS after successful detorsion
›Prevents recurrence
›Lower mortality than emergency surgery
Endoscopic fixation for high-risk patients
›Endoscopic options for non-operative candidates
›Endoscopic sigmoidopexy or colopexy
›Fixation of sigmoid to abdominal wall under endoscopic guidance
›Considered when operative intervention contraindicated
›Randomized controlled trial support for high-risk surgical elderly
›Percutaneous endoscopic colostomy
›Alternative fixation technique
›Reserved for highest surgical risk patients
›Patient selection
›High ASA class
›Significant cardiopulmonary comorbidity
›Surgeon and endoscopist shared decision
Bowel regimen and recurrence prevention
›Long-term bowel management
›High-fiber diet and adequate hydration
›Reduce chronic constipation
›Increase dietary fiber to 25-35 g per day
›Osmotic laxatives
›Polyethylene glycol 17 g orally daily
›Lactulose 15-30 mL orally twice daily as alternative
›Minimize constipating medications
›Review and reduce opioids when possible
›Switch anticholinergics to alternatives if feasible